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Improved Sleep Corr...
Improved Sleep Correlates with Improved Quality of Life and Motor Symptoms with Foslevodopa/Foscarbidopa
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Chaudhuri, K. Ray (author)
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Facheris, Maurizio F. (author)
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Bergmans, Bruno (author)
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- Bergquist, Filip, 1970 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för farmakologi,Institute of Neuroscience and Physiology, Department of Pharmacology
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Criswell, Susan R. (author)
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Jia, Jia (author)
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Kukreja, Pavnit (author)
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Mukai, Yohei (author)
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Spiegel, Amy M. (author)
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Gupta, Resmi (author)
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Bergmann, Lars (author)
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Pahwa, Rajesh (author)
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(creator_code:org_t)
- 2024
- 2024
- English.
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In: MOVEMENT DISORDERS CLINICAL PRACTICE. - 2330-1619.
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
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- Background: Foslevodopa/foscarbidopa is a subcutaneous infusion of levodopa/carbidopa prodrugs. Objectives: Assess correlations between sleep and efficacy from interim data of a phase 3 trial of foslevodopa/foscarbidopa (NCT03781167). Methods: Pearson correlations between sleep (Parkinson's Disease Sleep Scale-2 [PDSS-2]) and quality of life (QoL; Parkinson's Disease Questionnaire-39), motor experiences of daily living (m-EDL; Movement Disorder Society-Unified Parkinson's Disease Scale Part II), and "Off"/"On" times were calculated for baseline and week 26 improvements. Regression analyses were adjusted for baseline PDSS-2 score. Results: Baseline sleep correlated moderately with QoL (r = 0.44, P < 0.001) and weakly with m-EDL (r = 0.28; P < 0.001). Sleep improvement weakly correlated with improved "Off" time (r = 0.37; P < 0.001) and QoL (r = 0.36; P < 0.001). Regression analyses demonstrated significant positive associations for improved sleep, "Off" time, QoL, and m-EDL. Conclusions: Improved sleep with foslevodopa/foscarbidopa was associated with improved QoL and "Off" time.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- Parkinson's disease
- sleep
- infusion therapy
- foslevodopa/foscarbidopa
- post hoc analysis
Publication and Content Type
- ref (subject category)
- art (subject category)
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Chaudhuri, K. Ra ...
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Facheris, Mauriz ...
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Bergmans, Bruno
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Bergquist, Filip ...
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Criswell, Susan ...
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Jia, Jia
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show more...
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Kukreja, Pavnit
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Mukai, Yohei
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Spiegel, Amy M.
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Gupta, Resmi
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Bergmann, Lars
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Pahwa, Rajesh
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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MOVEMENT DISORDE ...
- By the university
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University of Gothenburg