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Longitudinal suppor...
Longitudinal support for the correlative triad among aging, dopamine D2-like receptor loss, and memory decline
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- Karalija, Nina, 1984- (author)
- Umeå universitet,Umeå centrum för funktionell hjärnavbildning (UFBI),Institutionen för medicinsk och translationell biologi
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- Papenberg, Goran (author)
- Karolinska Institutet
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- Johansson, Jarkko (author)
- Umeå universitet,Umeå centrum för funktionell hjärnavbildning (UFBI),Diagnostisk radiologi,Institutionen för diagnostik och intervention
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- Wåhlin, Anders (author)
- Umeå universitet,Umeå centrum för funktionell hjärnavbildning (UFBI),Institutionen för tillämpad fysik och elektronik,Institutionen för diagnostik och intervention,Radiofysik
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- Salami, Alireza (author)
- Karolinska Institutet,Umeå universitet,Umeå centrum för funktionell hjärnavbildning (UFBI),Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM),Institutionen för medicinsk och translationell biologi,Aging Research Center, Karolinska Institutet & Stockholm University, Stockholm, Sweden
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- Andersson, Micael (author)
- Umeå universitet,Umeå centrum för funktionell hjärnavbildning (UFBI),Institutionen för medicinsk och translationell biologi
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- Axelsson, Jan, 1966- (author)
- Umeå universitet,Umeå centrum för funktionell hjärnavbildning (UFBI),Radiofysik,Institutionen för diagnostik och intervention
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- Kuznetsov, Dmitry (author)
- Faculty of Sociology, University of Bielefeld, Bielefeld, Germany
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- Riklund, Katrine, MD, PhD, Professor, 1963- (author)
- Umeå universitet,Umeå centrum för funktionell hjärnavbildning (UFBI),Diagnostisk radiologi,Institutionen för diagnostik och intervention
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- Lövdén, Martin, 1972 (author)
- Karolinska Institutet,Gothenburg University,Göteborgs universitet,Psykologiska institutionen,Department of Psychology,Department of Psychology, University of Gothenburg, Göteborg, Sweden
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- Lindenberger, Ulman (author)
- Center for Lifespan Psychology, Max Planck Institute for Human Development, Berlin, Germany; Max Planck UCL Centre for Computational Psychiatry and Ageing Research, Berlin, Germany; Max Planck UCL Centre for Computational Psychiatry and Ageing Research, London, United Kingdom
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- Backman, Lars (author)
- Karolinska Institutet
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- Nyberg, Lars, 1966- (author)
- Umeå universitet,Umeå centrum för funktionell hjärnavbildning (UFBI),Diagnostisk radiologi,Institutionen för diagnostik och intervention,Institutionen för medicinsk och translationell biologi
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(creator_code:org_t)
- 2024
- 2024
- English.
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In: NEUROBIOLOGY OF AGING. - 0197-4580 .- 1558-1497. ; 136, s. 125-132
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Abstract
Subject headings
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- Dopamine decline is suggested to underlie aging -related cognitive decline, but longitudinal examinations of this link are currently missing. We analyzed 5 -year longitudinal data for a sample of healthy, older adults (baseline: n = 181, age: 64-68 years; 5 -year follow-up: n = 129) who underwent positron emission tomography with 11C- raclopride to assess dopamine D2 -like receptor (DRD2) availability, magnetic resonance imaging to evaluate structural brain measures, and cognitive tests. Health, lifestyle, and genetic data were also collected. A datadriven approach (k -means cluster analysis) identified groups that differed maximally in DRD2 decline rates in age -sensitive brain regions. One group (n = 47) had DRD2 decline exclusively in the caudate and no cognitive decline. A second group (n = 72) had more wide -ranged DRD2 decline in putamen and nucleus accumbens and also in extrastriatal regions. The latter group showed significant 5 -year working memory decline that correlated with putamen DRD2 decline, along with higher dementia and cardiovascular risk and a faster biological pace of aging. Taken together, for individuals with more extensive DRD2 decline, dopamine decline is associated with memory decline in aging.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Geriatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Geriatrics (hsv//eng)
Keyword
- Aging
- Longitudinal
- Working memory
- Positron emission tomography
- 11 C-raclopride
- Magnetic resonance imaging
- Dopamine D2-like receptor
- 11C-raclopride
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Karalija, Nina, ...
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Papenberg, Goran
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Johansson, Jarkk ...
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Wåhlin, Anders
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Salami, Alireza
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Andersson, Micae ...
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Axelsson, Jan, 1 ...
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Kuznetsov, Dmitr ...
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Riklund, Katrine ...
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Lövdén, Martin, ...
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Lindenberger, Ul ...
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Backman, Lars
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Nyberg, Lars, 19 ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Geriatrics
- Articles in the publication
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NEUROBIOLOGY OF ...
- By the university
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University of Gothenburg
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Umeå University
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Karolinska Institutet