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Pre-morbid sleep di...
Pre-morbid sleep disturbance and its association with stroke severity: results from the international INTERSTROKE study
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Mc Carthy, Christine E. (author)
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Yusuf, Salim (author)
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Judge, Conor (author)
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Ferguson, John (author)
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Hankey, Graeme J. (author)
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Gharan, Shahram Oveis (author)
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Damasceno, Albertino (author)
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Iversen, Helle Klingenberg (author)
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- Rosengren, Annika, 1951 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine
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Ogah, Okechukwu (author)
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Avezum, Luisa (author)
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Lopez-Jaramillo, Patricio (author)
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Xavier, Denis (author)
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Wang, Xingyu (author)
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Rangarajan, Sumathy (author)
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O'Donnell, Martin J. (author)
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(creator_code:org_t)
- 2024
- 2024
- English.
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In: EUROPEAN JOURNAL OF NEUROLOGY. - 1351-5101 .- 1468-1331.
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https://doi.org/10.1...
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Abstract
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- Background and purpose: Whilst sleep disturbances are associated with stroke, their association with stroke severity is less certain. In the INTERSTROKE study, the association of pre-morbid sleep disturbance with stroke severity and functional outcome following stroke was evaluated. Methods: INTERSTROKE is an international case-control study of first acute stroke. This analysis included cases who completed a standardized questionnaire concerning nine symptoms of sleep disturbance (sleep onset latency, duration, quality, nocturnal awakening, napping duration, whether a nap was planned, snoring, snorting and breathing cessation) in the month prior to stroke (n = 2361). Two indices were derived representing sleep disturbance (range 0-9) and obstructive sleep apnoea (range 0-3) symptoms. Logistic regression was used to estimate the magnitude of association between symptoms and stroke severity defined by the modified Rankin Score. Results: The mean age of participants was 62.9 years, and 42% were female. On multivariable analysis, there was a graded association between increasing number of sleep disturbance symptoms and initially severe stroke (2-3, odds ratio [OR] 1.44, 95% confidence interval [CI] 1.07-1.94; 4-5, OR 1.66, 95% CI 1.23-2.25; >5, OR 2.58, 95% CI 1.83-3.66). Having >5 sleep disturbance symptoms was associated with significantly increased odds of functional deterioration at 1 month (OR 1.54, 95% CI 1.01-2.34). A higher obstructive sleep apnoea score was also associated with significantly increased odds of initially severe stroke (2-3, OR 1.48; 95% CI 1.20-1.83) but not functional deterioration at 1 month (OR 1.19, 95% CI 0.93-1.52). Conclusions: Sleep disturbance symptoms were common and associated with an increased odds of severe stroke and functional deterioration. Interventions to modify sleep disturbance may help prevent disabling stroke/improve functional outcomes and should be the subject of future research.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- disability evaluation
- sleep
- sleep apnea
- obstructive
- sleep initiation and maintenance disorders
- stroke
Publication and Content Type
- ref (subject category)
- art (subject category)
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Mc Carthy, Chris ...
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Yusuf, Salim
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Judge, Conor
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Ferguson, John
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Hankey, Graeme J ...
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Gharan, Shahram ...
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show more...
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Damasceno, Alber ...
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Iversen, Helle K ...
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Rosengren, Annik ...
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Ogah, Okechukwu
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Avezum, Luisa
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Lopez-Jaramillo, ...
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Xavier, Denis
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Wang, Xingyu
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Rangarajan, Suma ...
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O'Donnell, Marti ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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EUROPEAN JOURNAL ...
- By the university
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University of Gothenburg