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Vascular risk burde...
Vascular risk burden is a key player in the early progression of Alzheimer's disease
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Ferrari-Souza, Joao Pedro (author)
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- Brum, Wagner S. (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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Hauschild, Lucas A. (author)
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Da Ros, Lucas U. (author)
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Ferreira, Pamela C. L. (author)
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Bellaver, Bruna (author)
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Leffa, Douglas T. (author)
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Bieger, Andrei (author)
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Tissot, Cecile (author)
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Lussier, Firoza Z. (author)
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De Bastiani, Marco Antonio (author)
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Povala, Guilherme (author)
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- Lessa Benedet, Andréa (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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Therriault, Joseph (author)
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Wang, Yi-Ting (author)
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- Ashton, Nicholas J. (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Zetterberg, Henrik, 1973 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Blennow, Kaj, 1958 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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Martins, Sheila O. (author)
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Souza, Diogo O. (author)
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Rosa-Neto, Pedro (author)
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- Karikari, Thomas (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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Pascoal, Tharick A. (author)
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Zimmer, Eduardo R. (author)
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(creator_code:org_t)
- 2024
- 2024
- English.
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In: NEUROBIOLOGY OF AGING. - 0197-4580 .- 1558-1497. ; 136, s. 88-98
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Abstract
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- Understanding whether vascular risk factors (VRFs) synergistically potentiate Alzheimer's disease (AD) progression is important in the context of emerging treatments for preclinical AD. In a group of 503 cognitively unimpaired individuals, we tested whether VRF burden interacts with AD pathophysiology to accelerate neurodegeneration and cognitive decline. Baseline VRF burden was calculated considering medical data and AD pathophysiology was assessed based on cerebrospinal fluid (CSF) amyloid-beta 1-42 (A beta 1-42) and tau phosphorylated at threonine 181 (p-tau181). Neurodegeneration was assessed with plasma neurofilament light (NfL) and global cognition with the modified version of the Preclinical Alzheimer's Cognitive Composite. The mean (SD) age of participants was 72.9 (6.1) years, and 220 (43.7%) were men. Linear mixed-effects models revealed that an elevated VRF burden synergistically interacted with AD pathophysiology to drive longitudinal plasma NfL increase and cognitive decline. Additionally, VRF burden was not associated with CSF A beta 1-42or p-tau181 changes over time. Our results suggest that VRF burden and AD pathophysiology are independent processes; however, they synergistically lead to neurodegeneration and cognitive deterioration. In preclinical stages, the combination of therapies targeting VRFs and AD pathophysiology might potentiate treatment outcomes.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- Vascular risk factor
- Alzheimer 's disease
- Cognitive decline
- Neurodegeneration
- Biomarker
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Ferrari-Souza, J ...
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Brum, Wagner S.
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Hauschild, Lucas ...
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Da Ros, Lucas U.
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Ferreira, Pamela ...
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Bellaver, Bruna
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show more...
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Leffa, Douglas T ...
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Bieger, Andrei
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Tissot, Cecile
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Lussier, Firoza ...
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De Bastiani, Mar ...
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Povala, Guilherm ...
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Lessa Benedet, A ...
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Therriault, Jose ...
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Wang, Yi-Ting
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Ashton, Nicholas ...
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Zetterberg, Henr ...
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Blennow, Kaj, 19 ...
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Martins, Sheila ...
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Souza, Diogo O.
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Rosa-Neto, Pedro
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Karikari, Thomas
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Pascoal, Tharick ...
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Zimmer, Eduardo ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
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NEUROBIOLOGY OF ...
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University of Gothenburg