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Diagnostic and prog...
Diagnostic and prognostic performance of the ratio between high-sensitivity cardiac troponin I and troponin T in patients with chest pain.
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- Eggers, Kai M., 1962- (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Uppsala kliniska forskningscentrum (UCR)
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- Hammarsten, Ola (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin,Institute of Biomedicine,Department of Clinical Chemistry, Sahlgrenska University Hopsital, Göteborg, Sweden
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- Aldous, Sally J (author)
- Department of Cardiology, Christchurch Hospital, Christchurch, New Zealand
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- Cullen, Louise (author)
- Emergency Department, Royal Brisbane and Women’s Hospital, Brisbane, Australia
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- Greenslade, Jaimi H (author)
- Emergency Department, Royal Brisbane and Women’s Hospital, Brisbane, Australia
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- Lindahl, Bertil, 1957- (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Uppsala kliniska forskningscentrum (UCR)
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- Parsonage, William A (author)
- Department of Cardiology, Royal Brisbane and Women’s Hospital, Brisbane, Australia
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- Pemberton, Christopher J (author)
- Christchurch Heart Institute, Department of Medicine, University of Ontago, Christchurch, New Zealand
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- Pickering, John W (author)
- Christchurch Heart Institute, Department of Medicine, University of Ontago, Christchurch, New Zealand, Emergency Department, Christchurch Hospital, Christchurch, New Zealand
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- Richards, A Mark (author)
- Christchurch Heart Institute, Department of Medicine, University of Ontago, Christchurch, New Zealand, Cardiovascular Research Institute, National University of Singapore, Singapore, Singapore
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- Troughton, Richard W (author)
- Christchurch Heart Institute, Department of Medicine, University of Ontago, Christchurch, New Zealand
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- Than, Martin P (author)
- Emergency Department, Christchurch Hospital, Christchurch, New Zealand
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(creator_code:org_t)
- 2022-11-01
- 2022
- English.
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In: PloS one. - : Public Library of Science (PLoS). - 1932-6203. ; 17:11
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Abstract
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- Elevations of high-sensitivity cardiac troponin (hs-cTn) concentrations not related to type 1 myocardial infarction are common in chest pain patients presenting to emergency departments. The discrimination of these patients from those with type 1 myocardial infarction (MI) is challenging and resource-consuming. We aimed to investigate whether the hs-cTn I/T ratio might provide diagnostic and prognostic increment in this context.We calculated the hs-cTn I/T ratio in 888 chest pain patients having hs-cTnI (Abbott Laboratories) or hs-cTnT (Roche Diagnostics) concentrations above the respective 99th percentile at 2 hours from presentation. All patients were followed for one year regarding mortality.The median hs-cTn I/T ratio was 3.45 (25th, 75th percentiles 1.80-6.59) in type 1 MI patients (n = 408 ☯46.0%]), 1.18 (0.81-1.90) in type 2 MI patients (n = 56 ☯6.3%]) and 0.67 (0.39-1.12) in patients without MI. The hs-cTn I/T ratio provided good discrimination of type 1 MI from no type 1 MI (area under the receiver-operator characteristic curve 0.89 ☯95% confidence interval 0.86-0.91]), of type 1 MI from type 2 MI (area under the curve 0.81 ☯95% confidence interval 0.74-0.87]), and was associated with type 1 MI in adjusted analyses. The hs-cTn I/T ratio provided no consistent prognostic value.The hs-cTn I/T ratio appears to be useful for early diagnosis of type 1 MI and its discrimination from type 2 MI in chest pain patients presenting with elevated hs-cTn. Differences in hs-cTn I/T ratio values may reflect variations in hs-cTn release mechanisms in response to different types of myocardial injury.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Biomedicinsk laboratorievetenskap/teknologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Biomedical Laboratory Science/Technology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Keyword
- Humans
- Biomarkers
- Chest Pain
- complications
- Myocardial Infarction
- complications
- Prognosis
- Troponin I
- Troponin T
Publication and Content Type
- ref (subject category)
- art (subject category)
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Eggers, Kai M., ...
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Hammarsten, Ola
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Aldous, Sally J
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Cullen, Louise
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Greenslade, Jaim ...
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Lindahl, Bertil, ...
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Parsonage, Willi ...
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Pemberton, Chris ...
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Pickering, John ...
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Richards, A Mark
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Troughton, Richa ...
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Than, Martin P
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Medical Biotechn ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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PloS one
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University of Gothenburg
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Uppsala University