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Investigating the R...
Investigating the Role of Brain Natriuretic Peptide (BNP) and N-Terminal-proBNP in Thrombosis and Acute Ischemic Stroke Etiology.
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Rossi, Rosanna (author)
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Jabrah, Duaa (author)
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Douglas, Andrew (author)
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Prendergast, James (author)
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Pandit, Abhay (author)
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Gilvarry, Michael (author)
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McCarthy, Ray (author)
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- Redfors, Petra (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience
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- Nordanstig, Annika, 1974 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience
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- Tatlisumak, Turgut (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience
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Ceder, Erik (author)
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Dunker, Dennis (author)
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Carlqvist, Jeanette (author)
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Szikora, István (author)
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Tsivgoulis, Georgios (author)
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Psychogios, Klearchos (author)
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Thornton, John (author)
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Rentzos, Alexandros, 1979 (author)
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- Jood, Katarina, 1966 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience
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Juega, Jesus (author)
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Doyle, Karen M (author)
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(creator_code:org_t)
- 2024
- 2024
- English.
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In: International Journal of Molecular Sciences. - 1661-6596 .- 1422-0067. ; 25:5
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https://doi.org/10.3...
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Abstract
Subject headings
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- The need for biomarkers for acute ischemic stroke (AIS) to understand the mechanisms implicated in pathological clot formation is critical. The levels of the brain natriuretic peptides known as brain natriuretic peptide (BNP) and NT-proBNP have been shown to be increased in patients suffering from heart failure and other heart conditions. We measured their expression in AIS clots of cardioembolic (CE) and large artery atherosclerosis (LAA) etiology, evaluating their location inside the clots, aiming to uncover their possible role in thrombosis. We analyzed 80 thrombi from 80 AIS patients in the RESTORE registry of AIS clots, 40 of which were of CE and 40 of LAA etiology. The localization of BNP and NT-BNP, quantified using immunohistochemistry and immunofluorescence, in AIS-associated white blood cell subtypes was also investigated. We found a statistically significant positive correlation between BNP and NT-proBNP expression levels (Spearman's rho = 0.668 p < 0.0001 *). We did not observe any statistically significant difference between LAA and CE clots in BNP expression (0.66 [0.13-3.54]% vs. 0.53 [0.14-3.07]%, p = 0.923) or in NT-proBNP expression (0.29 [0.11-0.58]% vs. 0.18 [0.05-0.51]%, p = 0.119), although there was a trend of higher NT-proBNP expression in the LAA clots. It was noticeable that BNP was distributed throughout the thrombus and especially within platelet-rich regions. However, NT-proBNP colocalized with neutrophils, macrophages, and T-lymphocytes, suggesting its association with the thrombo-inflammatory process.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Keyword
- Humans
- Natriuretic Peptide
- Brain
- Ischemic Stroke
- complications
- Heart Failure
- Thrombosis
- complications
- Causality
- Peptide Fragments
- Biomarkers
- Stroke
- etiology
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Rossi, Rosanna
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Jabrah, Duaa
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Douglas, Andrew
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Prendergast, Jam ...
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Pandit, Abhay
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Gilvarry, Michae ...
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show more...
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McCarthy, Ray
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Redfors, Petra
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Nordanstig, Anni ...
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Tatlisumak, Turg ...
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Ceder, Erik
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Dunker, Dennis
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Carlqvist, Jeane ...
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Szikora, István
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Tsivgoulis, Geor ...
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Psychogios, Klea ...
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Thornton, John
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Rentzos, Alexand ...
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Jood, Katarina, ...
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Juega, Jesus
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Doyle, Karen M
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
- Articles in the publication
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International Jo ...
- By the university
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University of Gothenburg