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Association between...
Association between overweight and obesity with coronary artery bypass graft failure: an individual patient data analysis of clinical trials.
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An, Kevin R (author)
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Sandner, Sigrid (author)
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- Redfors, Björn (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine
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Alexander, John H (author)
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Alzghari, Talal (author)
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Caldonazo, Tulio (author)
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Cancelli, Gianmarco (author)
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Dell'Aquila, Michele (author)
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Dimagli, Arnaldo (author)
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Gibson, C Michael (author)
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Harik, Lamia (author)
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Heise, Rachel (author)
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Kulik, Alexander (author)
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Lamy, Andre (author)
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Leith, Jordan (author)
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Peper, Joyce (author)
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Perezgrovas-Olaria, Roberto (author)
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Rossi, Camilla S (author)
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Ruel, Marc (author)
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Soletti, Giovanni (author)
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Ten Berg, Jurrien M (author)
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Willemsen, Laura M (author)
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Wojdyla, Daniel M (author)
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Zhao, Qiang (author)
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Zhu, Yunpeng (author)
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Verma, Subodh (author)
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Gaudino, Mario F L (author)
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(creator_code:org_t)
- 2024
- 2024
- English.
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In: European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery. - 1873-734X.
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Abstract
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- The association between obesity and graft failure after coronary artery bypass grafting has not been previously investigated.We pooled individual patient data from randomized clinical trials with systematic post-operative coronary imaging to evaluate the association between obesity and graft failure at the individual graft and patient levels. Penalized cubic regression splines and mixed-effects multivariable logistic regression models were performed.Six trials comprising 3,928 patients and 12,048 grafts were included. The median time to imaging was 1.03 (IQR, 1.00-1.09) years. By body mass index (BMI) category, 800 (20.4%) patients were normal weight (BMI 18.5-24.9), 1,668 (42.5%) were overweight (BMI 25-29.9), 983 (25.0%) were obesity class 1 (BMI 30-34.9), 344 (8.8%) were obesity class 2 (BMI 35-39.9), and 116 (2.9%) were obesity class 3 (BMI 40+). As a continuous variable, BMI was associated with reduced graft failure (adjusted odds ratio [aOR] 0.98 [95% CI, 0.97-0.99]) at the individual graft level. Compared to normal weight patients, graft failure at the individual graft level was reduced in overweight (aOR 0.79 [95% CI, 0.64-0.96]), obesity class 1 (aOR 0.81 [95% CI, 0.64-1.01]), and obesity class 2 (aOR 0.61 [95% CI, 0.45-0.83]) patients, but not different compared to obesity class 3 (aOR 0.94 [95% CI, 0.62-1.42]) patients. Findings were similar, but did not reach significance, at the patient level.In a pooled individual patient data analysis of randomized clinical trials, BMI and obesity appear to be associated with reduced graft failure at one year after coronary artery bypass grafting.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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An, Kevin R
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Sandner, Sigrid
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Redfors, Björn
-
Alexander, John ...
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Alzghari, Talal
-
Caldonazo, Tulio
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show more...
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Cancelli, Gianma ...
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Dell'Aquila, Mic ...
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Dimagli, Arnaldo
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Gibson, C Michae ...
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Harik, Lamia
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Heise, Rachel
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Kulik, Alexander
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Lamy, Andre
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Leith, Jordan
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Peper, Joyce
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Perezgrovas-Olar ...
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Rossi, Camilla S
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Ruel, Marc
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Soletti, Giovann ...
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Ten Berg, Jurrie ...
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Willemsen, Laura ...
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Wojdyla, Daniel ...
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Zhao, Qiang
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Zhu, Yunpeng
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Verma, Subodh
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Gaudino, Mario F ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
- Articles in the publication
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European journal ...
- By the university
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University of Gothenburg