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Lack of association...
Lack of association between classical HLA genes and asymptomatic SARS-CoV-2 infection.
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Marchal, Astrid (author)
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Cirulli, Elizabeth T (author)
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Neveux, Iva (author)
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Bellos, Evangelos (author)
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Thwaites, Ryan S (author)
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Schiabor Barrett, Kelly M (author)
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Zhang, Yu (author)
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Nemes-Bokun, Ivana (author)
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Kalinova, Mariya (author)
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Catchpole, Andrew (author)
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Tangye, Stuart G (author)
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Spaan, András N (author)
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Lack, Justin B (author)
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Ghosn, Jade (author)
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Burdet, Charles (author)
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Gorochov, Guy (author)
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Tubach, Florence (author)
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Hausfater, Pierre (author)
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- Ekwall, Olov, 1968 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institutionen för kliniska vetenskaper, Avdelningen för pediatrik,Institute of Medicine, Department of Rheumatology and Inflammation Research,Institute of Clinical Sciences, Department of Pediatrics
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Dalgard, Clifton L (author)
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Zhang, Shen-Ying (author)
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Zhang, Qian (author)
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Chiu, Christopher (author)
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Fellay, Jacques (author)
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Grzymski, Joseph J (author)
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Sancho-Shimizu, Vanessa (author)
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Abel, Laurent (author)
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Casanova, Jean-Laurent (author)
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Cobat, Aurélie (author)
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Bolze, Alexandre (author)
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(creator_code:org_t)
- 2024
- 2024
- English.
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In: HGG advances. - 2666-2477. ; 5:3
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https://doi.org/10.1...
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Abstract
Subject headings
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- Human genetic studies of critical COVID-19 pneumonia have revealed the essential role of type I interferon-dependent innate immunity to SARS-CoV-2 infection. Conversely, an association between the HLA-B∗15:01 allele and asymptomatic SARS-CoV-2 infection in unvaccinated individuals was recently reported, suggesting a contribution of pre-existing Tcell-dependent adaptive immunity. We report a lack of association of classical HLA alleles, including HLA-B∗15:01, with pre-omicron asymptomatic SARS-CoV-2 infection in unvaccinated participants in a prospective population-based study in the United States (191 asymptomatic vs. 945 symptomatic COVID-19 cases). Moreover, we found no such association in the international COVID Human Genetic Effort cohort (206 asymptomatic vs. 574 mild or moderate COVID-19 cases and 1,625 severe or critical COVID-19 cases). Finally, in the Human Challenge Characterisation study, the three HLA-B∗15:01 individuals infected with SARS-CoV-2 developed symptoms. As with other acute primary infections studied, no classical HLA alleles favoring an asymptomatic course of SARS-CoV-2 infection were identified.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Marchal, Astrid
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Cirulli, Elizabe ...
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Neveux, Iva
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Bellos, Evangelo ...
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Thwaites, Ryan S
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Schiabor Barrett ...
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show more...
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Zhang, Yu
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Nemes-Bokun, Iva ...
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Kalinova, Mariya
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Catchpole, Andre ...
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Tangye, Stuart G
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Spaan, András N
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Lack, Justin B
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Ghosn, Jade
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Burdet, Charles
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Gorochov, Guy
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Tubach, Florence
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Hausfater, Pierr ...
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Ekwall, Olov, 19 ...
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Dalgard, Clifton ...
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Zhang, Shen-Ying
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Zhang, Qian
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Chiu, Christophe ...
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Fellay, Jacques
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Grzymski, Joseph ...
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Sancho-Shimizu, ...
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Abel, Laurent
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Casanova, Jean-L ...
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Cobat, Aurélie
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Bolze, Alexandre
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Immunology in th ...
- Articles in the publication
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HGG advances
- By the university
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University of Gothenburg