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Lifestyle and incid...
Lifestyle and incident dementia: A COSMIC individual participant data meta-analysis
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Van Asbroeck, Stephanie (author)
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Kohler, Sebastian (author)
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van Boxtel, Martin P. J. (author)
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Lipnicki, Darren M. (author)
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Crawford, John D. (author)
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Castro-Costa, Erico (author)
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Lima-Costa, Maria Fernanda (author)
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Blay, Sergio Luis (author)
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Xiao, Shifu (author)
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Wang, Tao (author)
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Yue, Ling (author)
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Lipton, Richard B. (author)
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Katz, Mindy J. (author)
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Derby, Carol A. (author)
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Guerchet, Maelenn (author)
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Preux, Pierre-Marie (author)
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Mbelesso, Pascal (author)
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Norton, Joanna (author)
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Ritchie, Karen (author)
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- Skoog, Ingmar, 1954 (author)
- Gothenburg University,Göteborgs universitet,Centrum för åldrande och hälsa (AgeCap),Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Centre for Ageing and Health (Agecap),Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Najar, Jenna, 1990 (author)
- Gothenburg University,Göteborgs universitet,Centrum för åldrande och hälsa (AgeCap),Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Centre for Ageing and Health (Agecap),Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Rydberg Sterner, Therese (author)
- Stockholms universitet,Gothenburg University,Göteborgs universitet,Centrum för åldrande och hälsa (AgeCap),Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Centre for Ageing and Health (Agecap),Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry,Centrum för forskning om äldre och åldrande (ARC), (tills m KI),University of Gothenburg, Sweden
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Scarmeas, Nikolaos (author)
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Yannakoulia, Mary (author)
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Dardiotis, Themis (author)
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Rolandi, Elena (author)
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Davin, Annalisa (author)
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Rossi, Michele (author)
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Gureje, Oye (author)
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Ojagbemi, Akin (author)
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Bello, Toyin (author)
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Kim, Ki Woong (author)
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Han, Ji Won (author)
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Oh, Dae Jong (author)
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Trompet, Stella (author)
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Gussekloo, Jacobijn (author)
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Riedel-Heller, Steffi G. (author)
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Rohr, Susanne (author)
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Pabst, Alexander (author)
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Shahar, Suzana (author)
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Rivan, Nurul Fatin Malek (author)
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Singh, Devinder Kaur Ajit (author)
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Jacobsen, Erin (author)
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Ganguli, Mary (author)
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Hughes, Tiffany (author)
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Haan, Mary (author)
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Aiello, Allison E. (author)
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Ding, Ding (author)
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Zhao, Qianhua (author)
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Xiao, Zhenxu (author)
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Narazaki, Kenji (author)
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Chen, Tao (author)
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Chen, Sanmei (author)
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Ng, Tze Pin (author)
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Gwee, Xinyi (author)
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Gao, Qi (author)
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Brodaty, Henry (author)
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Trollor, Julian (author)
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Kochan, Nicole (author)
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Lobo, Antonio (author)
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Santabarbara, Javier (author)
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Gracia-Garcia, Patricia (author)
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Sachdev, Perminder S. (author)
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Deckers, Kay (author)
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(creator_code:org_t)
- 2024
- 2024
- English.
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In: ALZHEIMERS & DEMENTIA. - 1552-5260 .- 1552-5279. ; 20:6, s. 3972-3986
- Related links:
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https://doi.org/10.1...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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http://kipublication...
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Abstract
Subject headings
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- INTRODUCTIONThe LIfestyle for BRAin Health (LIBRA) index yields a dementia risk score based on modifiable lifestyle factors and is validated in Western samples. We investigated whether the association between LIBRA scores and incident dementia is moderated by geographical location or sociodemographic characteristics. METHODSWe combined data from 21 prospective cohorts across six continents (N = 31,680) and conducted cohort-specific Cox proportional hazard regression analyses in a two-step individual participant data meta-analysis. RESULTSA one-standard-deviation increase in LIBRA score was associated with a 21% higher risk for dementia. The association was stronger for Asian cohorts compared to European cohorts, and for individuals aged <= 75 years (vs older), though only within the first 5 years of follow-up. No interactions with sex, education, or socioeconomic position were observed. DISCUSSIONModifiable risk and protective factors appear relevant for dementia risk reduction across diverse geographical and sociodemographic groups. Highlights A two-step individual participant data meta-analysis was conducted. This was done at a global scale using data from 21 ethno-regionally diverse cohorts. The association between a modifiable dementia risk score and dementia was examined. The association was modified by geographical region and age at baseline. Yet, modifiable dementia risk and protective factors appear relevant in all investigated groups and regions.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Keyword
- age
- dementia
- dementia risk reduction
- education
- effect modification
- ethnicity
- individual participant data meta-analysis
- interaction
- lifestyle
- primary prevention
- region
- risk factor
- risk personalization
- sex
- socioeconomic
- age
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Van Asbroeck, St ...
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Kohler, Sebastia ...
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van Boxtel, Mart ...
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Lipnicki, Darren ...
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Crawford, John D ...
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Castro-Costa, Er ...
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show more...
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Lima-Costa, Mari ...
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Blay, Sergio Lui ...
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Xiao, Shifu
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Wang, Tao
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Yue, Ling
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Lipton, Richard ...
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Katz, Mindy J.
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Derby, Carol A.
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Guerchet, Maelen ...
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Preux, Pierre-Ma ...
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Mbelesso, Pascal
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Norton, Joanna
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Ritchie, Karen
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Skoog, Ingmar, 1 ...
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Najar, Jenna, 19 ...
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Rydberg Sterner, ...
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Scarmeas, Nikola ...
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Yannakoulia, Mar ...
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Dardiotis, Themi ...
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Rolandi, Elena
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Davin, Annalisa
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Rossi, Michele
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Gureje, Oye
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Ojagbemi, Akin
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Bello, Toyin
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Kim, Ki Woong
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Han, Ji Won
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Oh, Dae Jong
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Trompet, Stella
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Gussekloo, Jacob ...
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Riedel-Heller, S ...
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Rohr, Susanne
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Pabst, Alexander
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Shahar, Suzana
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Rivan, Nurul Fat ...
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Singh, Devinder ...
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Jacobsen, Erin
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Ganguli, Mary
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Hughes, Tiffany
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Haan, Mary
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Aiello, Allison ...
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Ding, Ding
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Zhao, Qianhua
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Xiao, Zhenxu
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Narazaki, Kenji
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Chen, Tao
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Chen, Sanmei
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Ng, Tze Pin
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Gwee, Xinyi
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Gao, Qi
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Brodaty, Henry
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Trollor, Julian
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Kochan, Nicole
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Lobo, Antonio
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Santabarbara, Ja ...
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Gracia-Garcia, P ...
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Sachdev, Permind ...
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Deckers, Kay
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Public Health Gl ...
- Articles in the publication
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ALZHEIMERS & DEM ...
- By the university
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University of Gothenburg
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Stockholm University
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Karolinska Institutet