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Has time to chemoth...
Has time to chemotherapy from primary debulking surgery in advanced ovarian cancer an impact on survival?- A population-based nationwide SweGCG study
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- Dahm-Kähler, Pernilla, 1964 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi,Institute of Clinical Sciences, Department of Obstetrics and Gynecology,Sahlgrenska Academy,Univ Gothenburg, Dept Obstet & Gynecol, Sahlgrenska Acad, Gothenburg, Sweden.;Reg Canc Ctr Western Sweden, Gothenburg, Sweden.;Gothenburg Univ, Dept Obstet & Gynecol, Sahlgrenska Acad, SE-41345 Gothenburg, Sweden.
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- Radestad, Angelique Floter (author)
- Karolinska Institutet,Karolinska Univ Hosp, Karolinska Inst, Dept Womens & Childrens Hlth, Div Obstet & Gynecol,Theme Canc, Stockholm, Sweden.;Karolinska Univ Hosp, Dept Hereditary Canc, Theme Canc, Stockholm, Sweden.
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- Holmberg, Erik (author)
- Reg Canc Ctr Western Sweden, Gothenburg, Sweden.
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- Borgfeldt, Christer (author)
- Lund University,Lunds universitet,Obstetrik och gynekologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Gynekologisk cancer, förebyggande av cancer och osteoporos,Forskargrupper vid Lunds universitet,Obstetrics and Gynaecology (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Gynecological Cancer and Cancer prevention as well as prevention of Osteoporosis,Lund University Research Groups,Skåne University Hospital,Skane Univ Hosp, Lund Univ, Dept Obstet & Gynecol, Lund, Sweden.;Lund Univ, Dept Clin Sci, Lund, Sweden.
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- Bjurberg, Maria (author)
- Lund University,Lunds universitet,Huvud- och halscancergruppen,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Bröst/ovarialcancer,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Head and Neck Cancer Research Group,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Breast/ovarian cancer,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital,Lund Univ, Skane Univ Hosp, Dept Hematol Oncol & Radiat Phys, Lund, Sweden.
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- Sköld, Camilla (author)
- Uppsala universitet,Uppsala University,Uppsala Univ, Sweden,Cancerprecisionsmedicin
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- Hellman, Kristina (author)
- Karolinska Institutet,Karolinska Univ Hosp, Dept Gynecol Canc, Theme Canc, Stockholm, Sweden.
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- Kjölhede, Preben (author)
- Linköpings universitet,Linköping University,Avdelningen för barns och kvinnors hälsa,Medicinska fakulteten,Region Östergötland, Kvinnokliniken US,Linköping Univ, Dept Obstet & Gynecol, Linköping, Sweden.;Linköping Univ, Dept Biomed & Clin Sci, Linköping, Sweden.
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- Stålberg, Karin (author)
- Uppsala universitet,Uppsala University,Uppsala Univ, Sweden,Reproduktiv hälsa
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- Åvall Lundqvist, Elisabeth (author)
- Linköpings universitet,Linköping University,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten,Region Östergötland, Onkologiska kliniken US,Linköping Univ, Dept Biomed & Clin Sci, Linköping, Sweden.;Linköping Univ, Dept Oncol, Linköping, Sweden.
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(creator_code:org_t)
- ACADEMIC PRESS INC ELSEVIER SCIENCE, 2024
- 2024
- English.
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In: GYNECOLOGIC ONCOLOGY. - : ACADEMIC PRESS INC ELSEVIER SCIENCE. - 0090-8258 .- 1095-6859. ; 186, s. 69-76
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Abstract
Subject headings
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- Objective. The aim of the study was to investigate if time to start chemotherapy (TTC) after primary debulking surgery (PDS) impacted relative survival (RS) in advanced epithelial ovarian/fallopian tube/primary peritoneal cancer (EOC). Methods. Nationwide population-based study of women with EOC FIGO stages IIIC-IV, registered 2008-2018 in the Swedish Quality Register for Gynecologic Cancer, treated with PDS and chemotherapy. TTC was categorized into; <= 21 days, 22-28 days, 29-35 days, 36-42 days and > 42 days. Relative survival (RS) was estimated using the Pohar-Perme estimate of net survival. Multivariable analyses of excess mortality rate ratios (EMRRs) were estimated by Poisson regression models. Results. In total, 1694 women were included. The median age was 65.0 years. Older age and no residual disease were more common in TTC >42 days than 0-21 days. The RS at 5-years was 37.9% and did not differ between TTC groups. In the R0 (no residual disease) cohort (n = 806), 2-year RS was higher in TTC <= 21 days (91.6%) and 22-28 days (91.4%) than TTC >42 days (79.1%). TTC >42 days (EMRR 2.33, p = 0.026), FIGO stage IV (EMRR 1.83, p = 0.007) and non-serous histology (EMRR 4.20, p < 0.001) were associated with 2-year worse excess mortality compared to TTC 0-21 days, in the R0 cohort. TTC was associated with 2-year survival in the R0 cohort in FIGO stage IV but not in stage IIIC. TTC was not associated with RS in patients with residual disease. Conclusions. For the entire cohort, stage IV, non-serous morphology and residual disease, but not TTC, influenced 5-year relative survival. However, longer TTC was associated with a poorer 2-year survival for those without residual disease after PDS. (c) 2024 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- Epithelial ovarian cancer
- Primary debulking surgery
- Time to chemotherapy
- Survival
- Residual disease
- Epithelial ovarian cancer; Primary debulking surgery; Time to chemotherapy; Survival; Residual disease
Publication and Content Type
- ref (subject category)
- art (subject category)
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Dahm-Kähler, Per ...
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Radestad, Angeli ...
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Holmberg, Erik
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Borgfeldt, Chris ...
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Bjurberg, Maria
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Sköld, Camilla
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Hellman, Kristin ...
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Kjölhede, Preben
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Stålberg, Karin
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Åvall Lundqvist, ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Obstetrics Gynae ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Surgery
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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GYNECOLOGIC ONCO ...
- By the university
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University of Gothenburg
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Lund University
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Karolinska Institutet
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Linköping University
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Uppsala University