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Longitudinal trajec...
Longitudinal trajectories of Alzheimer's disease CSF biomarkers and blood pressure in cognitively healthy subjects
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Biskaduros, Adrienne (author)
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Glodzik, Lidia (author)
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Saint Louis, Leslie A. (author)
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Rusinek, Henry (author)
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Pirraglia, Elizabeth (author)
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Osorio, Ricardo (author)
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Butler, Tracy (author)
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Li, Yi (author)
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Xi, Ke (author)
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Tanzi, Emily (author)
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Harvey, Patrick (author)
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- Zetterberg, Henrik, 1973 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Blennow, Kaj, 1958 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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de Leon, Mony J. (author)
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(creator_code:org_t)
- 2024
- 2024
- English.
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In: ALZHEIMERS & DEMENTIA. - 1552-5260 .- 1552-5279.
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Abstract
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- INTRODUCTION: We examined whether hypertension (HTN) was associated with Alzheimer's disease-related biomarkers in cerebrospinal fluid (CSF) and how changes in blood pressure (BP) related to changes in CSF biomarkers over time. METHODS: A longitudinal observation of cognitively healthy normotensive subjects (n = 134, BP < 140/90, with no antihypertensive medication), controlled HTN (n = 36, BP < 140/90, taking antihypertensive medication), and 35 subjects with uncontrolled HTN (BP >= 140/90). The follow-up range was 0.5to15.6 years. RESULTS: Total tau (T-tau) and phospho-tau181 (P-tau 181) increased in all but controlled HTN subjects (groupxtime interaction: p < 0.05 for both), but no significant A beta 42 changes were seen. Significant BP reduction was observed in uncontrolled HTN, and it was related to increase in T-tau (p = 0.001) and P-tau 181 (p < 0.001). DISCUSSION: Longitudinal increases in T-tau and P-tau 181 were observed in most subjects; however, only uncontrolled HTN had both markers increase alongside BP reductions. We speculate cumulative vascular injury renders the brain susceptible to relative hypoperfusion with BP reduction.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- Alzheimer's disease
- CSF biomarkers
- neurodegeneration
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Biskaduros, Adri ...
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Glodzik, Lidia
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Saint Louis, Les ...
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Rusinek, Henry
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Pirraglia, Eliza ...
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Osorio, Ricardo
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show more...
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Butler, Tracy
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Li, Yi
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Xi, Ke
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Tanzi, Emily
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Harvey, Patrick
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Zetterberg, Henr ...
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Blennow, Kaj, 19 ...
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de Leon, Mony J.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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ALZHEIMERS & DEM ...
- By the university
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University of Gothenburg