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A plasma protein-ba...
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Austin, Thomas R.
(author)
A plasma protein-based risk score to predict hip fractures
- Article/chapterEnglish2024
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LIBRIS-ID:oai:gup.ub.gu.se/339309
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https://gup.ub.gu.se/publication/339309URI
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https://doi.org/10.1038/s43587-024-00639-7DOI
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
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As there are effective treatments to reduce hip fractures, identification of patients at high risk of hip fracture is important to inform efficient intervention strategies. To obtain a new tool for hip fracture prediction, we developed a protein-based risk score in the Cardiovascular Health Study using an aptamer-based proteomic platform. The proteomic risk score predicted incident hip fractures and improved hip fracture discrimination in two Tr & oslash;ndelag Health Study validation cohorts using the same aptamer-based platform. When transferred to an antibody-based proteomic platform in a UK Biobank validation cohort, the proteomic risk score was strongly associated with hip fractures (hazard ratio per s.d. increase, 1.64; 95% confidence interval 1.53-1.77). The proteomic risk score, but not available polygenic risk scores for fractures or bone mineral density, improved the C-index beyond the fracture risk assessment tool (FRAX), which integrates information from clinical risk factors (C-index, FRAX 0.735 versus FRAX + proteomic risk score 0.776). The developed proteomic risk score constitutes a new tool for stratifying patients according to hip fracture risk; however, its improvement in hip fracture discrimination is modest and its clinical utility beyond FRAX with information on femoral neck bone mineral density remains to be determined. The authors developed a proteomic risk score that improved the prediction of hip fractures in three validation cohorts analyzed by two different proteomic platforms. This risk score constitutes a new tool to stratify patients by hip fracture risk.
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Nethander, Maria,1980Gothenburg University,Göteborgs universitet,Core Facilities, Bioinformatics,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Centre for Bone and Arthritis Research,Core Facilities, Bioinformatics,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition(Swepub:gu)xnetma
(author)
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Fink, Howard A.
(author)
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Törnqvist, Anna EGothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Centre for Bone and Arthritis Research,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition(Swepub:gu)xbannf
(author)
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Jalal, Diana I.
(author)
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Buzkova, Petra
(author)
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Barzilay, Joshua I.
(author)
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Carbone, Laura
(author)
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Gabrielsen, Maiken E.
(author)
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Grahnemo, LouiseGothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition(Swepub:gu)xstlou
(author)
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Lu, Tianyuan
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Hveem, Kristian
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Jonasson, Christian
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Kizer, Jorge R.
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Langhammer, Arnulf
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Mukamal, Kenneth J.
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Gerszten, Robert E.
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Psaty, Bruce M.
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Robbins, John A.
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Sun, Yan V.
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Skogholt, Anne Heidi
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Kanis, John A.
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Johansson, Helena,1981Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Centre for Bone and Arthritis Research,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition(Swepub:gu)xjhell
(author)
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Asvold, Bjorn Olav
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Valderrabano, Rodrigo J.
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Zheng, Jie
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Richards, J. Brent
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Coward, Eivind
(author)
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Ohlsson, Claes,1965Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Centre for Bone and Arthritis Research,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition(Swepub:gu)xohlcl
(author)
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Göteborgs universitetCore Facilities, Bioinformatics
(creator_code:org_t)
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Austin, Thomas R ...
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Nethander, Maria ...
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Fink, Howard A.
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Törnqvist, Anna ...
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Jalal, Diana I.
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Buzkova, Petra
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Barzilay, Joshua ...
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Carbone, Laura
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Gabrielsen, Maik ...
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Grahnemo, Louise
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Lu, Tianyuan
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Hveem, Kristian
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Jonasson, Christ ...
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Kizer, Jorge R.
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Langhammer, Arnu ...
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Mukamal, Kenneth ...
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Gerszten, Robert ...
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Psaty, Bruce M.
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Robbins, John A.
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Sun, Yan V.
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Skogholt, Anne H ...
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Kanis, John A.
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Johansson, Helen ...
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Asvold, Bjorn Ol ...
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Valderrabano, Ro ...
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Zheng, Jie
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Richards, J. Bre ...
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Coward, Eivind
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Ohlsson, Claes, ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Orthopaedics
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NATURE AGING
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University of Gothenburg