Search: onr:"swepub:oai:gup.ub.gu.se/339510" >
β-lactamase express...
β-lactamase expression induces collateral sensitivity in Escherichia coli
-
Herencias, Cristina (author)
-
Alvaro-Llorente, Laura (author)
-
Ramiro-Martinez, Paula (author)
-
show more...
-
Fernandez-Calvet, Ariadna (author)
-
Munoz-Cazalla, Ada (author)
-
DelaFuente, Javier (author)
-
- Graf, Fabrice (author)
- Gothenburg University,Göteborgs universitet,CARe - Centrum för antibiotikaresistensforskning,Institutionen för kemi och molekylärbiologi,Centre for antibiotic resistance research, CARe,Department of Chemistry and Molecular Biology
-
Jaraba-Soto, Laura (author)
-
Castillo-Polo, Juan Antonio (author)
-
Canton, Rafael (author)
-
San Millan, Alvaro (author)
-
Rodriguez-Beltran, Jeronimo (author)
-
show less...
-
(creator_code:org_t)
- 2024
- 2024
- English.
-
In: NATURE COMMUNICATIONS. - 2041-1723. ; 15:1
- Related links:
-
https://gup.ub.gu.se...
-
show more...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- Major antibiotic groups are losing effectiveness due to the uncontrollable spread of antimicrobial resistance (AMR) genes. Among these, beta-lactam resistance genes -encoding beta-lactamases- stand as the most common resistance mechanism in Enterobacterales due to their frequent association with mobile genetic elements. In this context, novel approaches that counter mobile AMR are urgently needed. Collateral sensitivity (CS) occurs when the acquisition of resistance to one antibiotic increases susceptibility to another antibiotic and can be exploited to eliminate AMR selectively. However, most CS networks described so far emerge as a consequence of chromosomal mutations and cannot be leveraged to tackle mobile AMR. Here, we dissect the CS response elicited by the acquisition of a prevalent antibiotic resistance plasmid to reveal that the expression of the beta-lactamase gene bla OXA-48 induces CS to colistin and azithromycin. We next show that other clinically relevant mobile beta-lactamases produce similar CS responses in multiple, phylogenetically unrelated E. coli strains. Finally, by combining experiments with surveillance data comprising thousands of antibiotic susceptibility tests, we show that beta-lactamase-induced CS is pervasive within Enterobacterales. These results highlight that the physiological side-effects of beta-lactamases can be leveraged therapeutically, paving the way for the rational design of specific therapies to block mobile AMR or at least counteract their effects.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Herencias, Crist ...
-
Alvaro-Llorente, ...
-
Ramiro-Martinez, ...
-
Fernandez-Calvet ...
-
Munoz-Cazalla, A ...
-
DelaFuente, Javi ...
-
show more...
-
Graf, Fabrice
-
Jaraba-Soto, Lau ...
-
Castillo-Polo, J ...
-
Canton, Rafael
-
San Millan, Alva ...
-
Rodriguez-Beltra ...
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Infectious Medic ...
- Articles in the publication
-
NATURE COMMUNICA ...
- By the university
-
University of Gothenburg