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Acromegaly manageme...
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Arlien-Soborg, Mai C.Aarhus Univ Hosp, Denmark,Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark
(author)
Acromegaly management in the Nordic countries: A Delphi consensus survey
- Article/chapterEnglish2024
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LIBRIS-ID:oai:gup.ub.gu.se/339527
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https://gup.ub.gu.se/publication/339527URI
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https://doi.org/10.1111/cen.15095DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-205153URI
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-226954URI
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
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Funding Agencies|Pfizer
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ObjectiveAcromegaly is associated with increased morbidity and mortality if left untreated. The therapeutic options include surgery, medical treatment, and radiotherapy. Several guidelines and recommendations on treatment algorithms and follow-up exist. However, not all recommendations are strictly evidence-based. To evaluate consensus on the treatment and follow-up of patients with acromegaly in the Nordic countries.MethodsA Delphi process was used to map the landscape of acromegaly management in Denmark, Sweden, Norway, Finland, and Iceland. An expert panel developed 37 statements on the treatment and follow-up of patients with acromegaly. Dedicated endocrinologists (n = 47) from the Nordic countries were invited to rate their extent of agreement with the statements, using a Likert-type scale (1-7). Consensus was defined as >= 80% of panelists rating their agreement as >= 5 or <= 3 on the Likert-type scale.ResultsConsensus was reached in 41% (15/37) of the statements. Panelists agreed that pituitary surgery remains first line treatment. There was general agreement to recommend first-generation somatostatin analog (SSA) treatment after failed surgery and to consider repeat surgery. In addition, there was agreement to recommend combination therapy with first-generation SSA and pegvisomant as second- or third-line treatment. In more than 50% of the statements, consensus was not achieved. Considerable disagreement existed regarding pegvisomant monotherapy, and treatment with pasireotide and dopamine agonists.ConclusionThis consensus exploration study on the management of patients with acromegaly in the Nordic countries revealed a relatively large degree of disagreement among experts, which mirrors the complexity of the disease and the shortage of evidence-based data.
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Dal, JakobAalborg Univ Hosp, Denmark; Steno Diabet Ctr North Jutland, Denmark,Department of Endocrinology, Aalborg University Hospital, Aarhus, Denmark; Steno Diabetes Center North Jutland, Aalborg, Denmark
(author)
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Heck, AnsgarOslo Univ Hosp, Norway,Oslo University Hospital, Oslo, Norway
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Stochholm, KirstineAarhus Univ Hosp, Denmark,Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark
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Husted, EigilAalborg Univ Hosp, Denmark,Department of Endocrinology, Aalborg University Hospital, Aarhus, Denmark
(author)
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Feltoft, Claus LarsenCopenhagen Univ Hosp Herlev & Gentofte, Denmark,Copenhagen University Hospital—Herlev and Gentofte, Kobenhavn, Denmark
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Rasmussen, ase KroghCopenhagen Univ Hosp, Denmark,Copenhagen University Hospital, Kobenhavn, Denmark
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Feldt-Rasmussen, UllaCopenhagen Univ Hosp, Denmark,Copenhagen University Hospital, Kobenhavn, Denmark
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Andreassen, MikkelCopenhagen Univ Hosp, Denmark,Copenhagen University Hospital, Kobenhavn, Denmark
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Klose, Marianne ChristinaCopenhagen Univ Hosp, Denmark,Copenhagen University Hospital, Kobenhavn, Denmark
(author)
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Nielsen, Torben LeoOdense Univ Hosp, Denmark,Odense University Hospital, Odense, Denmark
(author)
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Andersen, Marianne SkovsagerOdense Univ Hosp, Denmark,Odense University Hospital, Odense, Denmark
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Christensen, Louise LehmannOdense Univ Hosp, Denmark,Odense University Hospital, Odense, Denmark
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Krogh, JesperCopenhagen Univ Hosp, Denmark,Copenhagen University Hospital, Kobenhavn, Denmark
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Jarlov, AnneCopenhagen Univ Hosp, Denmark,Copenhagen University Hospital, Kobenhavn, Denmark
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Bollerslev, JensOslo Univ Hosp, Norway,Oslo University Hospital, Oslo, Norway
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Nermoen, IngridAkershus Univ Hosp, Norway,Akershus University Hospital, lørenskog, Norway
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Oksnes, MarianneHaukeland Hosp, Norway,Haukeland University Hospital, Bergen, Norway
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Dahlqvist, PerUmeå universitet,Institutionen för folkhälsa och klinisk medicin,Norrlands University Hospital, Umeå, Sweden(Swepub:umu)perdat96
(author)
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Olsson, TommyUmeå universitet,Institutionen för folkhälsa och klinisk medicin,Norrlands University Hospital, Umeå, Sweden(Swepub:umu)tool0003
(author)
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Berinder, KatarinaKarolinska Univ Hosp, Sweden,Karolinska University Hospital, Sweden
(author)
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Hoybye, CharlotteKarolinska Univ Hosp, Sweden,Karolinska University Hospital, Sweden
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Petersson, MariaKarolinska Univ Hosp, Sweden,Karolinska University Hospital, Sweden
(author)
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Akerman, Anna-karinOrebro Univ, Sweden,School of Medical Sciences, Faculty of Medicine and Health, Örebro University, Sweden; Department of Medicine, Örebro University Hospital, Örebro, Sweden
(author)
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Wahlberg, JeanetteOrebro Univ Hosp, Sweden,Department of Medicine, Örebro University Hospital, Örebro, Sweden
(author)
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Ekman, BertilLinköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Medicinkliniken ViN,Region Östergötland, Endokrinmedicinska kliniken,Department of Endocrinology and the Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden(Swepub:liu)berek83
(author)
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Engstrom, Britt EdenUppsala Univ Hosp, Sweden,Uppsala University Hospital, Uppsala, Sweden
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Johannsson, Gudmundur,1960Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition,Sahlgrens Univ Hosp, Sweden; Univ Gothenburg, Sweden; Sahlgrens Univ Hosp, Sweden,Department of Endocrinology, Sahlgrenska University Hospital, Göteborg, Sweden; Department of Internal Medicine and Clinical Nutrition, Sahlgrenska Academy, University of Gothenburg & Sahlgrenska University Hospital, Gothenburg, Sweden(Swepub:gu)xjgudn
(author)
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Ragnarsson, OskarSahlgrens Univ Hosp, Sweden,Department of Endocrinology, Sahlgrenska University Hospital, Göteborg, Sweden
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Olsson, Daniel S,1983Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition,Sahlgrens Univ Hosp, Sweden; Univ Gothenburg, Sweden; AstraZeneca, Sweden,Department of Endocrinology, Sahlgrenska University Hospital, Göteborg, Sweden; Department of Internal Medicine and Clinical Nutrition, Sahlgrenska Academy, University of Gothenburg & Sahlgrenska University Hospital, Gothenburg, Sweden; Cardiovascular, Renal and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden(Swepub:gu)xolssd
(author)
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Sigurjonsdottir, Helga agustaNatl Univ Hosp Iceland, Iceland; Univ Iceland, Iceland,The National University Hospital of Iceland, Gothenburg, Iceland; School of Medicine, University of Iceland, Reykjavik, Iceland
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Fougner, Stine LyngviTrondheim Reg & Univ Hosp, Norway; Norwegian Univ Sci & Technol NTNU, Norway,Department of Endocrinology, St. Olavs hospital, Trondheim University Hospital, Trondheim, Norway; Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology (NTNU), Trondheim, Norway
(author)
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Matikainen, NiinaHelsinki Univ Hosp, Finland,Helsinki University Hospital, Helsinki, Finland
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Vehkavaara, SatuHelsinki Univ Hosp, Finland,Helsinki University Hospital, Helsinki, Finland
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Metso, SaaraTampere Univ Hosp, Finland,Tampere University Hospital, Tampere, Finland
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Jaatinen, PiaTampere Univ Hosp, Finland,Tampere University Hospital, Tampere, Finland
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Haemalainen, PaeiviTampere Univ Hosp, Finland,Tampere University Hospital, Tampere, Finland
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Rintamaki, ReetaKuopio Univ Hosp, Finland,Kuopio University Hospital, Kuopio, Finland
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Yliaska, IinaOulu Univ Hosp, Finland,Oulu University Hospital, Oulu, Finland
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Immonen, HeidiTurku Univ Hosp, Finland,Turku University Hospital, Turku, Finland
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Makimattila, SariHelsinki Univ Hosp, Finland,Helsinki University Hospital, Helsinki, Finland
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Cederberg-Tamminen, HennaHelsinki Univ Hosp, Finland,Helsinki University Hospital, Helsinki, Finland
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Viukari, MariannaHelsinki Univ Hosp, Finland,Helsinki University Hospital, Helsinki, Finland
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Nevalainen, PasiTampere Univ Hosp, Finland,Tampere University Hospital, Tampere, Finland
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Nuutila, PirjoTurku Univ Hosp, Finland,Turku University Hospital, Turku, Finland
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Schalin-Jantti, CamillaHelsinki Univ Hosp, Finland,Helsinki University Hospital, Helsinki, Finland
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Burman, PiaLund Univ, Sweden,Skåne University Hospital, Lund University, Malmö, Sweden
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Jorgensen, Jens Otto LundeAarhus Univ Hosp, Denmark,Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark
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Aarhus Univ Hosp, DenmarkDepartment of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark
(creator_code:org_t)
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In:CLINICAL ENDOCRINOLOGY: WILEY0300-06641365-2265
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Arlien-Soborg, M ...
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Dal, Jakob
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Heck, Ansgar
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Stochholm, Kirst ...
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Husted, Eigil
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Feltoft, Claus L ...
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Rasmussen, ase K ...
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Feldt-Rasmussen, ...
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Andersen, Marian ...
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Christensen, Lou ...
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Krogh, Jesper
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Jarlov, Anne
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Bollerslev, Jens
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Nermoen, Ingrid
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Oksnes, Marianne
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Dahlqvist, Per
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Olsson, Tommy
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Berinder, Katari ...
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Hoybye, Charlott ...
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Petersson, Maria
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Akerman, Anna-ka ...
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Wahlberg, Jeanet ...
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Ekman, Bertil
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Engstrom, Britt ...
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Ragnarsson, Oska ...
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Olsson, Daniel S ...
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Fougner, Stine L ...
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Haemalainen, Pae ...
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Rintamaki, Reeta
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