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Urinary concentrati...
Urinary concentrations of phthalate/DINCH metabolites and body mass index among European children and adolescents in the HBM4EU Aligned Studies: A cross-sectional multi-country study
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Desalegn, Anteneh (author)
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Schillemans, Tessa (author)
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Papadopoulou, Eleni (author)
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Sakhi, Amrit K. (author)
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Haug, Line S. (author)
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Caspersen, Ida Henriette (author)
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Rodriguez-Carrillo, Andrea (author)
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Remy, Sylvie (author)
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Schoeters, Greet (author)
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Covaci, Adrian (author)
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Laeremans, Michelle (author)
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Fernandez, Mariana F. (author)
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Pedraza-Diaz, Susana (author)
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Jensen, Tina Kold (author)
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Frederiksen, Hanne (author)
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- Akesson, Agneta (author)
- Karolinska Institutet
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Cox, Bianca (author)
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D'Cruz, Shereen Cynthia (author)
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Rambaud, Loic (author)
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Riou, Margaux (author)
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Kolossa-Gehring, Marike (author)
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Gerofke, Antje (author)
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Murawski, Aline (author)
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Vogel, Nina (author)
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Gabriel, Catherine (author)
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Karakitsios, Spyros (author)
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Papaioannou, Nafsika (author)
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Sarigiannis, Dimosthenis (author)
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Barbone, Fabio (author)
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Rosolen, Valentina (author)
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Lignell, Sanna (author)
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- Lindroos, Anna-Karin, 1958 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition
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Tratnik, Janja Snoj (author)
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Stajnko, Anja (author)
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Kosjek, Tina (author)
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Tkalec, Ziga (author)
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Fabelova, Lucia (author)
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Murinova, Lubica Palkovicova (author)
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Kolena, Branislav (author)
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Wimmerova, Sona (author)
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Szigeti, Tamas (author)
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Kozepesy, Szilvia (author)
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van den Brand, Annick (author)
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Zock, Jan-Paul (author)
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Janasik, Beata (author)
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Wasowicz, Wojciech (author)
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De Decker, Annelies (author)
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De Henauw, Stefaan (author)
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Govarts, Eva (author)
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Iszatt, Nina (author)
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(creator_code:org_t)
- 2024
- 2024
- English.
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In: ENVIRONMENT INTERNATIONAL. - 0160-4120 .- 1873-6750. ; 190
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https://doi.org/10.1...
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Abstract
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- Background: Phthalates are ubiquitous in the environment. Despite short half-lives, chronic exposure can lead to endocrine disruption. The safety of phthalate substitute DINCH is unclear. Objective: To evaluate associations between urinary concentrations of phthalate/DINCH metabolites and body mass index (BMI) z-score among children and adolescents. Method: We used Human Biomonitoring for Europe Aligned Studies data from 2876 children (12 studies, 6-12 years, 2014-2021) and 2499 adolescents (10 studies, 12-18 years, 2014-2021) with up to 14 phthalate/DINCH urinary metabolites. We used multilevel linear regression to assess associations between phthalate/DINCH concentrations and BMI z-scores, testing effect modification by sex. In a subset, Bayesian kernel machine regression (BKMR) and quantile-based g-computation assessed important predictors and mixture effects. Results: In children, we found few associations in single pollutant models and no interactions by sex (p p-interaction > 0.1). BKMR detected no relevant exposures (posterior inclusion probabilities, PIPs < 0.25), nor joint mixture effect. In adolescent single pollutant analysis, mono-ethyl phthalate (MEP) concentrations were associated with higher BMI z-score in males ((3 = 0.08, 95% CI: 0.001,0.15, per interquartile range increase in ln-transformed concentrations, p-interaction = 0.06). Conversely, mono-isobutyl phthalate (MiBP) was associated with a lower BMI z-score in both sexes ((3 =-0.13, 95 % CI:-0.19,-0.07, p-interaction = 0.74), as was sum of di(2-ethylhexyl) phthalate (& sum;DEHP) metabolites in females only ((3 =-0.08,95 % CI:-0.14,-0.02,p-interaction p-interaction = 0.01). In BKMR, higher BMI z-scores were predicted by MEP (PIP=0.90) and MBzP (PIP=0.84) in males. Lower BMI z-scores were predicted by MiBP (PIP=0.999), OH-MIDP (PIP=0.88) and OH-MINCH (PIP=0.72) in both sexes, less robustly by DEHP (PIP=0.61) in females. In quantile g-computation, the overall mixture effect was null for males, and trended negative for females ((3 =-0.11, 95 % CI:-0.25, 0.03, per joint exposure quantile). Conclusion: In this large Europe-wide study, we found age/sex-specific differences between phthalate metabolites and BMI z-score, stronger in adolescents. Longitudinal studies with repeated phthalate measurements are needed.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences (hsv//eng)
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- ref (subject category)
- art (subject category)
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Desalegn, Antene ...
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Schillemans, Tes ...
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Papadopoulou, El ...
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Sakhi, Amrit K.
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Haug, Line S.
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Caspersen, Ida H ...
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show more...
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Rodriguez-Carril ...
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Remy, Sylvie
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Schoeters, Greet
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Covaci, Adrian
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Laeremans, Miche ...
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Fernandez, Maria ...
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Pedraza-Diaz, Su ...
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Jensen, Tina Kol ...
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Frederiksen, Han ...
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Akesson, Agneta
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Cox, Bianca
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D'Cruz, Shereen ...
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Rambaud, Loic
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Riou, Margaux
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Kolossa-Gehring, ...
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Gerofke, Antje
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Murawski, Aline
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Vogel, Nina
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Gabriel, Catheri ...
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Karakitsios, Spy ...
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Papaioannou, Naf ...
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Sarigiannis, Dim ...
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Barbone, Fabio
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Rosolen, Valenti ...
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Lignell, Sanna
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Lindroos, Anna-K ...
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Tratnik, Janja S ...
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Stajnko, Anja
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Kosjek, Tina
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Tkalec, Ziga
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Fabelova, Lucia
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Murinova, Lubica ...
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Kolena, Branisla ...
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Wimmerova, Sona
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Szigeti, Tamas
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Kozepesy, Szilvi ...
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van den Brand, A ...
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Zock, Jan-Paul
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Janasik, Beata
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Wasowicz, Wojcie ...
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De Decker, Annel ...
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De Henauw, Stefa ...
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Govarts, Eva
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Iszatt, Nina
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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ENVIRONMENT INTE ...
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University of Gothenburg
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Karolinska Institutet