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The genetic landscape of neuro-related proteins in human plasma

Repetto, Linda (author)
Chen, Jiantao (author)
Yang, Zhijian (author)
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Zhai, Ranran (author)
Timmers, Paul R. H. J. (author)
Feng, Xiao (author)
Li, Ting (author)
Yao, Yue (author)
Maslov, Denis (author)
Timoshchuk, Anna (author)
Tu, Fengyu (author)
Twait, Emma L. (author)
May-Wilson, Sebastian (author)
Muckian, Marisa D. (author)
Prins, Bram P. (author)
Png, Grace (author)
Kooperberg, Charles (author)
Johansson, Asa (author)
Hillary, Robert F. (author)
Wheeler, Eleanor (author)
Pan, Lu (author)
He, Yazhou (author)
Klasson, Sofia (author)
Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för laboratoriemedicin,Department of Laboratory Medicine
Ahmad, Shahzad (author)
Peters, James E. (author)
Gilly, Arthur (author)
Karaleftheri, Maria (author)
Tsafantakis, Emmanouil (author)
Haessler, Jeffrey (author)
Gyllensten, Ulf (author)
Harris, Sarah E. (author)
Wareham, Nicholas J. (author)
Göteson, Andreas, 1991 (author)
Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
Lagging, Cecilia (author)
Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för laboratoriemedicin,Department of Laboratory Medicine
Ikram, Mohammad Arfan (author)
van Duijn, Cornelia M. (author)
Jern, Christina, 1962 (author)
Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för laboratoriemedicin,Department of Laboratory Medicine
Landén, Mikael, 1966 (author)
Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
Langenberg, Claudia (author)
Deary, Ian J. (author)
Marioni, Riccardo E. (author)
Enroth, Stefan (author)
Reiner, Alexander P. (author)
Dedoussis, George (author)
Zeggini, Eleftheria (author)
Sharapov, Sodbo (author)
Aulchenko, Yurii S. (author)
Butterworth, Adam S. (author)
Maelarstig, Anders (author)
Wilson, James F. (author)
Navarro, Pau (author)
Shen, Xia (author)
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 (creator_code:org_t)
2024
2024
English.
In: NATURE HUMAN BEHAVIOUR. - 2397-3374.
Related links:
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https://doi.org/10.1...
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  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Understanding the genetic basis of neuro-related proteins is essential for dissecting the molecular basis of human behavioural traits and the disease aetiology of neuropsychiatric disorders. Here the SCALLOP Consortium conducted a genome-wide association meta-analysis of over 12,000 individuals for 184 neuro-related proteins in human plasma. The analysis identified 125 cis-regulatory protein quantitative trait loci (cis-pQTL) and 164 trans-pQTL. The mapped pQTL capture on average 50% of each protein's heritability. At the cis-pQTL, multiple proteins shared a genetic basis with human behavioural traits such as alcohol and food intake, smoking and educational attainment, as well as neurological conditions and psychiatric disorders such as pain, neuroticism and schizophrenia. Integrating with established drug information, the causal inference analysis validated 52 out of 66 matched combinations of protein targets and diseases or side effects with available drugs while suggesting hundreds of repurposing and new therapeutic targets. Repetto et al. provide an analysis of the genetic basis of variation of neuro-related protein levels in plasma and link this to human behaviour and disorders.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine (hsv//eng)

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art (subject category)

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