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Blood-based multivariate methylation risk score for cognitive impairment and dementia

Koetsier, Jarno (author)
Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience (MHeNs), Faculty of Health, Medicine and Life Sciences (FHML), Maastricht University, Maastricht, The Netherlands; Department of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Faculty of Health, Medicine and Life Sciences (FHML), Maastricht University, Maastricht, The Netherlands
Cavill, Rachel (author)
Reijnders, Rick (author)
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Harvey, Joshua (author)
Homann, Jan (author)
Kouhsar, Morteza (author)
Deckers, Kay (author)
Kohler, Sebastian (author)
Eijssen, Lars M. T. (author)
van den Hove, Daniel L. A. (author)
Demuth, Ilja (author)
Duezel, Sandra (author)
Smith, Rebecca G. (author)
Smith, Adam R. (author)
Burrage, Joe (author)
Walker, Emma M. (author)
Shireby, Gemma (author)
Hannon, Eilis (author)
Dempster, Emma (author)
Frayling, Tim (author)
Mill, Jonathan (author)
Dobricic, Valerija (author)
Johannsen, Peter (author)
Wittig, Michael (author)
Franke, Andre (author)
Vandenberghe, Rik (author)
Schaeverbeke, Jolien (author)
Freund-Levi, Yvonne, 1956- (author)
Örebro universitet,Institutionen för medicinska vetenskaper,Department of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, Stockholm, Sweden; Department of Geriatrics, Södertälje Hospital, Södertälje, Sweden
Froelich, Lutz (author)
Scheltens, Philip (author)
Teunissen, Charlotte E. (author)
Frisoni, Giovanni (author)
Blin, Olivier (author)
Richardson, Jill C. (author)
Bordet, Regis (author)
Engelborghs, Sebastiaan (author)
de Roeck, Ellen (author)
Martinez-Lage, Pablo (author)
Tainta, Mikel (author)
Lleo, Alberto (author)
Sala, Isabel (author)
Popp, Julius (author)
Peyratout, Gwendoline (author)
Verhey, Frans (author)
Tsolaki, Magda (author)
Andreasson, Ulf, 1968 (author)
Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
Blennow, Kaj, 1958 (author)
Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
Zetterberg, Henrik, 1973 (author)
Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
Streffer, Johannes (author)
Vos, Stephanie J. B. (author)
Lovestone, Simon (author)
Visser, Pieter-Jelle (author)
Lill, Christina M. (author)
Bertram, Lars (author)
Lunnon, Katie (author)
Pishva, Ehsan (author)
Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience (MHeNs), Faculty of Health, Medicine and Life Sciences (FHML), Maastricht University, Maastricht, The Netherlands; Medical School, Faculty of Health and Life Sciences, University of Exeter, Exeter, UK
Alzheimer's Disease Neuroimaging Initiative, - (contributor)
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 (creator_code:org_t)
John Wiley & Sons, 2024
2024
English.
In: ALZHEIMERS & DEMENTIA. - : John Wiley & Sons. - 1552-5260 .- 1552-5279.
Related links:
https://doi.org/10.1...
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https://urn.kb.se/re...
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  • Journal article (peer-reviewed)
Abstract Subject headings
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  • INTRODUCTION: The established link between DNA methylation and pathophysiology of dementia, along with its potential role as a molecular mediator of lifestyle and environmental influences, positions blood-derived DNA methylation as a promising tool for early dementia risk detection. METHODS: In conjunction with an extensive array of machine learning techniques, we employed whole blood genome-wide DNA methylation data as a surrogate for 14 modifiable and non-modifiable factors in the assessment of dementia risk in independent dementia cohorts. RESULTS: We established a multivariate methylation risk score (MMRS) for identifying mild cognitive impairment cross-sectionally, independent of age and sex (P = 2.0 x 10(-3)). This score significantly predicted the prospective development of cognitive impairments in independent studies of Alzheimer's disease (hazard ratio for Rey's Auditory Verbal Learning Test (RAVLT)-Learning = 2.47) and Parkinson's disease (hazard ratio for MCI/dementia = 2.59). DISCUSSION: Our work shows the potential of employing blood-derived DNA methylation data in the assessment of dementia risk.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Neurosciences (hsv//eng)

Keyword

aging
Alzheimer's disease
dementia
DNA methylation
epigenetics
machine learning
mild cognitive impairments
Parkinson's disease
risk prediction
Alzheimer's disease

Publication and Content Type

ref (subject category)
art (subject category)

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