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Search: onr:"swepub:oai:gup.ub.gu.se/35867" > A microarray search...

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  • Sjöholm, Kajsa,1971Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för kroppssammansättning och metabolism,Institute of Internal Medicine, Dept of Body Composition and Metabolism (author)

A microarray search for genes predominantly expressed in human omental adipocytes: adipose tissue as a major production site of serum amyloid A.

  • Article/chapterEnglish2005

Publisher, publication year, extent ...

  • The Endocrine Society,2005

Numbers

  • LIBRIS-ID:oai:gup.ub.gu.se/35867
  • https://gup.ub.gu.se/publication/35867URI
  • https://doi.org/10.1210/jc.2004-1830DOI

Supplementary language notes

  • Language:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • To identify genes predominantly expressed in omental adipocytes, microarray expression profiles from 33 human tissues or cell types were analyzed, using an algorithm developed for identification of transcripts predominantly expressed in a certain tissue. Both known adipocyte-specific and more unexpected genes were among the 28 genes identified. To validate the approach, adipocyte expression of three of these genes, acute-phase serum amyloid A (A-SAA), aquaporin 7, and transport secretion protein-2.2, was compared with 17 other human tissues by real-time PCR. The unexpectedly high expression of A-SAA in adipocytes was further verified by Northern blot and immunohistochemistry. The liver, reported to be the main production site for A-SAA, displayed the second highest expression using microarray and real-time PCR. In obese subjects, adipose tissue mRNA and serum A-SAA levels were down-regulated during an 18-wk diet regime (P < 0.05 and P < 0.0001, respectively). A-SAA serum levels were highly correlated to adipose tissue mRNA levels (P < 0.001) and to the total (P < 0.0001) and sc (P < 0.0001) adipose tissue areas, as analyzed by computed tomography. We show that adipose tissue is a major expression site of A-SAA during the nonacute-phase reaction condition. This provides a direct link between adipose tissue mass and a marker for low-grade inflammation and cardiovascular risk.

Added entries (persons, corporate bodies, meetings, titles ...)

  • Palming, Jenny,1975Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för kroppssammansättning och metabolism,Institute of Internal Medicine, Dept of Body Composition and Metabolism(Swepub:gu)xpalje (author)
  • Olofsson, Louise,1977Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för kroppssammansättning och metabolism,Institute of Internal Medicine, Dept of Body Composition and Metabolism(Swepub:gu)xolofl (author)
  • Gummesson, Anders,1973Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory(Swepub:gu)xguman (author)
  • Svensson, Per-Arne,1969Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för kroppssammansättning och metabolism,Institute of Internal Medicine, Dept of Body Composition and Metabolism(Swepub:gu)xsvper (author)
  • Lystig, Ted (author)
  • Jennische, Eva,1949Gothenburg University,Göteborgs universitet,Institutionen för anatomi och cellbiologi,Institute of Anatomy and Cell Biology(Swepub:gu)xjenne (author)
  • Brandberg, John,1966Gothenburg University,Göteborgs universitet,Institutionen för särskilda specialiteter, Avdelningen för radiologi,Institute of Selected Clinical Sciences, Department of Radiology(Swepub:gu)xbrjoh (author)
  • Torgerson, Jarl S,1960Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för kroppssammansättning och metabolism,Institute of Internal Medicine, Dept of Body Composition and Metabolism (author)
  • Carlsson, Björn,1958 (author)
  • Carlsson, Lena M S,1957Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för kroppssammansättning och metabolism,Institute of Internal Medicine, Dept of Body Composition and Metabolism(Swepub:gu)xcarle (author)
  • Göteborgs universitetInstitutionen för invärtesmedicin, Avdelningen för kroppssammansättning och metabolism (creator_code:org_t)

Related titles

  • In:Journal of Clinical Endocrinology & Metabolism: The Endocrine Society90:4, s. 2233-90021-972X1945-7197

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