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Insulin resistance,...
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Welin, Lennart,1941
(author)
Insulin resistance, glucose intolerance, physical activity and other risk factors for coronary heart disease in elderly men. The study of men born in 1913 and 1923.
- Article/chapterEnglish2003
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LIBRIS-ID:oai:gup.ub.gu.se/36317
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https://gup.ub.gu.se/publication/36317URI
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
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BACKGROUND: We have previously shown that insulin is not a major risk factor for CHD. Our data have been re-analysed with longer follow-up and the homeostasis model assessment (HOMA) method. DESIGN: Prospective cohort study of 57- and 67-year-old men. METHODS: Insulin resistance was estimated with the HOMA equation. Standard methods were used to measure risk factors. The endpoint (CHD) was the combination of non-fatal myocardial infarction and fatal CHD during 13 years of follow-up. RESULTS: The risk of CHD increased 2.5-fold in known diabetics compared with those with normal glucose tolerance, 2.2-fold among those in the highest compared with the lowest quintile of insulin resistance, and 2.4-fold among those in the highest compared with the lowest quintile of fasting insulin. Increased physical activity decreased the risk of CHD by 65%. Cholesterol was also a significant risk factor for CHD but blood pressure, obesity and smoking were not related to the incidence of CHD. CONCLUSION: Insulin resistance is a significant risk factor for CHD. Whether it is a causal risk factor remains to be proven. Regular physical activity protects against CHD. PMID: 14555884 [PubMed - indexed for MEDLINE]
Added entries (persons, corporate bodies, meetings, titles ...)
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Bresäter, Lars-Einar,1949
(author)
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Eriksson, Henry,1946
(author)
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Hansson, Per-Olof,1958
(author)
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Welin, Catharina,1945Gothenburg University,Göteborgs universitet,Institutionen för omvårdnad,Institute of Nursing(Swepub:gu)xwelca
(author)
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Rosengren, Annika,1951
(author)
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Göteborgs universitetInstitutionen för omvårdnad
(creator_code:org_t)
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In:European Journal of Cardiovascular Prevention and Rehabilitation:10, s. 283-2881741-8267
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