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- Almkvist, Jenny,1971Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för reumatologi och inflammationsforskning,Institute of Internal Medicine, Dept of Rheumatology and Inflammation Research (author)
Newcastle disease virus neuraminidase primes neutrophils for stimulation by galectin-3 and formyl-Met-Leu-Phe
- Article/chapterEnglish2004
Publisher, publication year, extent ...
- Elsevier BV,2004
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- LIBRIS-ID:oai:gup.ub.gu.se/38783
- https://gup.ub.gu.se/publication/38783URI
- https://doi.org/10.1016/j.yexcr.2004.04.006DOI
- https://lup.lub.lu.se/record/272867URI
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- Language:English
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Notes
- Human neutrophils are activated by the beta-galactoside-binding lectin galectin-3, provided that the cells are primed by in vivo extravasation or by in vitro preactivation with, for example, LPS. Removal of terminal sialic acid can change neutrophil functionality and responsiveness due to exposure of underlying glycoconjugate receptors or change in surface charge. Here, we investigated whether such alteration of the cell surface carbohydrate composition can alter the responsiveness of the cells to galectin-3. Neutrophils were treated with neuraminidases (NA) of different origins: Clostridium perfringens (CP), Salmonella typhimurium, Vibrio cholerae, and Newcastle disease virus (NDV). In the presence of NDV-NA, but no other NA, the otherwise non-responding neutrophils responded readily to galectin-3 by activation of the NADPH-oxidase. The galectin-3 priming effect was inhibited by the sialidase inhibitor 2,3-dehydro-2-deoxy-N-acetyl-neuraminic acid. Earlier studies have shown that priming of the neutrophil response to galectin-3 with, for example, LPS is paralleled by degranulation of intracellular vesicles and granules and upregulation of potential galectin-3 receptors. Also, NDV-NA (but not CP-NA) treatment induced degranulation, shown as an upregulation of complement receptor 3. Since not only the galectin response but also the response to the chemoattractant fMLF was primed, NDV-NA appears to induce a general priming phenomenon, possibly due to receptor upregulation by degranulation.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Mikrobiologi inom det medicinska området hsv//swe
- MEDICAL AND HEALTH SCIENCES Basic Medicine Microbiology in the medical area hsv//eng
- MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Immunologi inom det medicinska området hsv//swe
- MEDICAL AND HEALTH SCIENCES Basic Medicine Immunology in the medical area hsv//eng
- Cell Degranulation/drug effects/immunology/physiology
- Chemotaxis
- Leukocyte/immunology
- Enzyme Inhibitors/pharmacology
- Galectin 3/*immunology/metabolism
- Humans
- Membrane Glycoproteins/drug effects/immunology
- N-Acetylneuraminic Acid/metabolism
- N-Formylmethionine Leucyl-Phenylalanine/*immunology/metabolism
- NADPH Oxidase/metabolism
- Neuraminidase/antagonists & inhibitors/*immunology/metabolism/pharmacology
- Neutrophil Activation/*immunology
- Neutrophils/drug effects/*immunology/virology
- Newcastle disease virus/*enzymology/immunology
- Receptors
- Cell Surface/drug effects/immunology
- Receptors
- Complement/drug effects/immunology
- Respiratory Burst/drug effects/immunology/physiology
- Secretory Vesicles/drug effects/metabolism
- Temperature
- Up-Regulation/drug effects/immunology
- Viral Proteins/immunology
- respiratory burst
- inflammation
- galectins
- neutrophils
Added entries (persons, corporate bodies, meetings, titles ...)
- Dahlgren, Claes,1949Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för reumatologi och inflammationsforskning,Institute of Internal Medicine, Dept of Rheumatology and Inflammation Research(Swepub:gu)xdahcl (author)
- Leffler, HakonLund University,Lunds universitet,Avdelningen för mikrobiologi, immunologi och glykobiologi - MIG,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Microbiology, Immunology and Glycobiology - MIG,Department of Laboratory Medicine,Faculty of Medicine(Swepub:lu)mmb-hle (author)
- Karlsson, Anna,1967Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för reumatologi och inflammationsforskning,Institute of Internal Medicine, Dept of Rheumatology and Inflammation Research(Swepub:gu)xkannb (author)
- Göteborgs universitetInstitutionen för invärtesmedicin, Avdelningen för reumatologi och inflammationsforskning (creator_code:org_t)
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- In:Experimental cell research: Elsevier BV298:1, s. 74-820014-48271090-2422
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