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Effect of exercise ...
Effect of exercise on ovarian morphology and expression of nerve growth factor and alpha(1)- and beta(2)-adrenergic receptors in rats with steroid-induced polycystic ovaries
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- Manni, Luigi, 1962 (author)
- Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory
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Cajander, S. (author)
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Lundeberg, T. (author)
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- Naylor, Andrew Stuart, 1977 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för fysiologi och farmakologi, Avdelningen för fysiologi,Institute of Physiology and Pharmacology, Dept of Physiology
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Aloe, L. (author)
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- Holmäng, Agneta, 1959 (author)
- Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory
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- Jonsdottir, Ingibjörg H, 1966 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för fysiologi och farmakologi, Avdelningen för fysiologi,Institute of Physiology and Pharmacology, Dept of Physiology
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- Stener-Victorin, Elisabet, 1964 (author)
- Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Institutionen för kvinnors och barns hälsa, Avdelningen för obstetrik och gynekologi,Wallenberg Laboratory,Institute for the Health of Women and Children, Dept of Obstetrics and Gynaecology
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(creator_code:org_t)
- 2005
- 2005
- English.
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In: J Neuroendocrinol. ; 17:12, s. 846-58
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Abstract
Subject headings
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- Oestadiol valerate (EV)-induced polycystic ovaries (PCO) in rats cause anovulation and cystic ovarian morphology. Denervation of ovarian sympathetic nerves restores ovulatory disruption. In the present study, we determined whether 5 weeks of voluntary exercise influence ovarian morphology and the expression of sympathetic markers in the EV-induced PCO rat model. The effect of exercise on (i) ovarian morphology; (ii) mRNA and protein expression of nerve growth factor (NGF); and (iii) mRNA and number of ovarian-expressing cells for the NGF receptor (p75 neurotrophin receptor) and the alpha(1a)-, alpha(1b)-, alpha(1d)- and beta(2)-adrenergic receptors (ARs) in rats with EV-induced PCO was evaluated. PCO was induced by a single i.m. injection of EV, and controls were injected with oil alone in adult cycling rats. The rats were divided into four groups: (i) control (oil); (ii) exercise group (oil + exercise); (iii) a PCO group (EV); and (iv) a PCO exercise group (EV + exercise). The exercise and PCO exercise groups ran voluntarily for 5 weeks in computer-monitored wheels placed in the cages where they were housed. The results obtained indicated that ovarian morphology was almost normalised in the PCO exercise group; NGF mRNA and protein concentrations were normalised in the PCO exercise group; high numbers of NGF receptor expressing cells in PCO ovaries were lowered by exercise; and the number of immunopositive cells of the different AR subtypes were all reduced after exercise in the PCO group, except for the alpha(1b)- and beta(2)-AR whereas the mRNA levels were unaffected, indicating transcriptional regulation. In conclusion, our data indicate a beneficial effect of regular exercise, as a modulator of ovarian sympathetic innervation, in the prevention and treatment of human PCOS.
Keyword
- Animals
- Body Weight
- Estradiol/analogs & derivatives
- Exertion/*physiology
- Female
- Nerve Growth Factor/*genetics
- Organ Size
- Ovary/innervation/pathology/physiopathology
- Polycystic Ovary Syndrome/chemically induced/pathology/*physiopathology
- RNA
- Messenger/analysis
- Rats
- Rats
- Inbred WKY
- Receptor
- Nerve Growth Factor/genetics
- Receptors
- Adrenergic
- alpha-1/*genetics
- Receptors
- Adrenergic
- beta-2/*genetics
- Sympathetic Nervous System/physiology
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Manni, Luigi, 19 ...
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Cajander, S.
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Lundeberg, T.
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Naylor, Andrew S ...
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Aloe, L.
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Holmäng, Agneta, ...
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show more...
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Jonsdottir, Ingi ...
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Stener-Victorin, ...
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- Articles in the publication
- J Neuroendocrino ...
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University of Gothenburg