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Riboflavin in innate and acquired immune responses

Verdrengh, Margareta, 1942 (author)
Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för reumatologi och inflammationsforskning,Institute of Internal Medicine, Dept of Rheumatology and Inflammation Research
Tarkowski, Andrej, 1951 (author)
Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för reumatologi och inflammationsforskning,Institute of Internal Medicine, Dept of Rheumatology and Inflammation Research
 (creator_code:org_t)
Springer Science and Business Media LLC, 2005
2005
English.
In: Inflamm Res. - : Springer Science and Business Media LLC. - 1023-3830. ; 54:9, s. 390-3
  • Journal article (peer-reviewed)
Abstract Subject headings
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  • OBJECTIVE AND DESIGN: Riboflavin, also known as vitamin B2, is a micronutrient with a key role in maintaining human health. It has also been shown to enhance host resistance to bacterial infections in mice. The aim of this study was to assess the role of vitamin B2 treatment in inflammatory conditions. SUBJECTS AND METHODS: Three models of inflammatory states were assessed. One of them encompasses neutrophil mediated but T cell/macrophage independent cutaneous inflammation. Another one is delayed type hypersensitivity reaction (DTH), a T cell/macrophage dependent but neutrophil independent inflammatory response. The third one is collagen- induced arthritis, having components from both of the above described reactions. Mice were treated with vitamin B2, administered by peritoneal injections, throughout the course of the experiments. RESULTS: The granulocyte dependent reaction to olive oil was significantly reduced in vitamin B2 treated mice. In contrast, DTH reactivity and collagen II arthritis were not affected by the treatment. CONCLUSION: Riboflavin administration affects neutrophil migration but does not alter acquired immune responsiveness.

Keyword

Animals
Antibody Formation/*drug effects
Arthritis
Experimental/pathology
Dermatitis/pathology
Edema/*chemically induced/*pathology
Foot
Hypersensitivity
Delayed/pathology
Injections
Intradermal
Injections
Intraperitoneal
Macrophages
Mice
Mice
Inbred Strains
*Neutrophils/drug effects
Plant Oils/administration & dosage
Riboflavin/administration & dosage/*pharmacology
T-Lymphocytes
Vitamin B Complex/administration & dosage/*pharmacology

Publication and Content Type

ref (subject category)
art (subject category)

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