Bronchial inflammation in chronic bronchitis assessed by measurement of cell products in bronchial lavage fluid

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Bronchial inflammation in chronic bronchitis assessed by measurement of cell products in bronchial lavage fluid

Riise, Gerdt C., 1956 (author): Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin,Institute of Internal Medicine

Ahlstedt, S. (author)

Larsson, Sven, 1943 (author): Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin,Institute of Internal Medicine

Enander, I. (author)

Jones, I. (author)

Larsson, Peter, 1946 (author): Gothenburg University,Göteborgs universitet,Institutionen för medicinsk mikrobiologi och immunologi,Institute of Medical Microbiology/Immunology

Andersson, Bengt A., 1952 (author): Gothenburg University,Göteborgs universitet,Institutionen för medicinsk mikrobiologi och immunologi,Institute of Medical Microbiology/Immunology

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(creator_code:org_t)

1995
1995
English.
In: Thorax. - 0040-6376. ; 50:4, s. 360-5

Related links:: https://gup.ub.gu.se...

Journal article (peer-reviewed)

Abstract Subject headings

BACKGROUND--Bronchial inflammation in chronic bronchitis has not been characterised as well as in asthma. The present study was undertaken to assess whether a characteristic pattern of bronchial inflammatory markers could be found in patients with chronic bronchitis. METHODS--Bronchoscopy with bronchial lavage was performed in 42 patients with chronic bronchitis and in 13 healthy controls. Twenty three of the patients had non-obstructive chronic bronchitis and 19 had chronic bronchitis and chronic obstructive pulmonary disease (COPD). Eighteen of the patients with bronchitis had recurrent infective exacerbations and 24 did not. Intrabronchial bacterial cultures were taken with a protected specimen brush. RESULTS--Increased activity of neutrophils, fibroblasts, and eosinophils was found in the patients with chronic bronchitis as assessed by the levels of myeloperoxidase (MPO) and interleukin-8 (IL-8), hyaluronan, and eosinophil cationic protein (ECP), respectively. The levels of tryptase did not differ from the controls. High correlations were found between the levels of MPO and IL-8, as well as ECP and IL-8. No differences were found between the patients with COPD and those with non-obstructive chronic bronchitis. CONCLUSIONS--Recruitment and activation of both neutrophils and eosinophils seem to be a characteristic of chronic bronchitis. This activation is associated with IL-8. The patients with intrabronchial cultures of Streptococcus pneumoniae had the highest individual levels of MPO, ECP, and IL-8 of all subjects in the study, indicating that colonisation with S pneumoniae could promote bronchial inflammation.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Dermatologi och venereologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Dermatology and Venereal Diseases (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)

Keyword

Adult
Aged
Biological Markers/analysis
Blood Proteins/analysis
Bronchitis/microbiology/*pathology
Bronchoalveolar Lavage Fluid/*chemistry/microbiology
Chronic Disease
Eosinophil Granule Proteins
Eosinophils/pathology
Fibroblasts/pathology
Humans
Hyaluronic Acid/analysis
Interleukin-8/analysis
Lung Diseases
Obstructive/pathology
Middle Aged
Neutrophils/pathology
Peroxidase/analysis
*Ribonucleases
Streptococcus pneumoniae/isolation & purification

Publication and Content Type

ref (subject category)
art (subject category)

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Dermatology and ...

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Microbiology in ...

Articles in the publication: Thorax

By the university: University of Gothenburg

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