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Liver transplantati...
Liver transplantation for primary sclerosing cholangitis; predictors and consequences of hepatobiliary malignancy
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- Brandsaeter, B. (author)
- Karolinska Institutet
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Isoniemi, H. (author)
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Broome, U. (author)
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- Olausson, Michael, 1956 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för de kirurgiska disciplinerna, Avdelningen för kirurgi,Institute of Surgical Sciences, Department of Surgery
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Backman, L. (author)
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Hansen, B. (author)
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Schrumpf, E. (author)
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Oksanen, A. (author)
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Ericzon, B. G. (author)
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Hockerstedt, K. (author)
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Makisalo, H. (author)
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Kirkegaard, P. (author)
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- Friman, Styrbjörn, 1948 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för de kirurgiska disciplinerna, Avdelningen för kirurgi,Institute of Surgical Sciences, Department of Surgery
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Bjoro, K. (author)
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(creator_code:org_t)
- Elsevier BV, 2004
- 2004
- English.
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In: Journal of hepatology. - : Elsevier BV. - 0168-8278. ; 40:5, s. 815-22
- Related links:
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https://doi.org/10.1...
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Abstract
Subject headings
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- BACKGROUND/AIMS: Hepatobiliary malignancies are frequently seen in primary sclerosing cholangitis (PSC) and they complicate the evaluation of patients and timing of liver transplantation. METHODS: Data from all Nordic PSC patients listed for liver transplantation during 1990-2001 were recorded prospectively. Predictors of hepatobiliary malignancy and patient survival rates have been analysed. RESULTS: Hepatobiliary malignancy was found in 52/255 (20%) patients accepted to the waiting list. Recent diagnosis of PSC, no ursodeoxycholic acid (UDCA) treatment, clinical suspicion and previous colorectal-cancer were predictors of malignancy. Among 89 patients with a strong suspicion of malignancy prior to acceptance, 35 (39%) had confirmed malignancy. A clinical suspicion had been raised in 35/52 (67%) patients with malignancy. Malignancy was found in 31/223 patients who received a liver allograft. The 1-, 3- and 5-year patient survival rates following transplantation for patients with PSC and cholangiocarcinoma were 65, 35 and 35%, respectively. CONCLUSIONS: Hepatobiliary malignancy is suspected in 1/3 of the PSC patients and found in 1/5. Although cholangiocarcinoma is regarded as a contraindication to liver transplantation (LTX), PSC patients with cholangiocarcinoma had a 35% 5-year survival following transplantation.
Keyword
- Adult
- Biliary Tract Neoplasms/*complications
- Carcinoma
- Hepatocellular/complications
- Cholangiocarcinoma/complications
- Cholangitis
- Sclerosing/*complications/mortality/*surgery
- Colorectal Neoplasms/complications
- Female
- Gallbladder Neoplasms/complications
- Humans
- Liver Neoplasms/*complications
- *Liver Transplantation/contraindications
- Male
- Middle Aged
- Prognosis
- Survival Rate
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Brandsaeter, B.
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Isoniemi, H.
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Broome, U.
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Olausson, Michae ...
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Backman, L.
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Hansen, B.
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show more...
-
Schrumpf, E.
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Oksanen, A.
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Ericzon, B. G.
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Hockerstedt, K.
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Makisalo, H.
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Kirkegaard, P.
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Friman, Styrbjör ...
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Bjoro, K.
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show less...
- Articles in the publication
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Journal of hepat ...
- By the university
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University of Gothenburg
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Karolinska Institutet