Search: onr:"swepub:oai:gup.ub.gu.se/47804" >
Actions by angioten...
Actions by angiotensin II on esophageal contractility in humans
-
- Casselbrant, Anna, 1970 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences
-
- Edebo, Anders, 1968 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences
-
- Wennerblom, Johanna, 1969 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences
-
show more...
-
- Lönroth, Hans, 1952 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences
-
- Helander, Herbert F, 1935 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences
-
Vieth, M. (author)
-
- Lundell, L. (author)
- Karolinska Institutet
-
- Fändriks, Lars, 1956 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences
-
show less...
-
(creator_code:org_t)
- Elsevier BV, 2007
- 2007
- English.
-
In: Gastroenterology. - : Elsevier BV. - 0016-5085. ; 132:1, s. 249-60
- Related links:
-
https://gup.ub.gu.se...
-
show more...
-
http://kipublication...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- BACKGROUND & AIMS: Angiotensin II is a potent activator of smooth muscles but has not been much investigated with regard to gastrointestinal motor activity. This study explores expression of the renin-angiotensin system (RAS) in human esophageal musculature and actions by Angiotensin II both in vitro and in vivo. METHODS: Muscular specimens of esophageal body and lower esophageal sphincter were obtained from patients undergoing resection as a result of mucosal neoplasm. Healthy volunteers participated in functional examinations of esophageal motility assessed by high-resolution manometry and multiple transmucosal potential-difference measurements. RESULTS: Gene transcripts of key components of RAS were found in the esophageal musculature. Immunohistochemistry revealed a distinct staining for Angiotensin II type 1 (AT(1)) receptors in the muscular bundles and blood-vessel walls, whereas Angiotensin II type 2 receptors were confined to blood vessels only. Angiotensin II caused concentration-dependent contractions in vitro, which were inhibited by the AT(1) receptor antagonist losartan but not by the Angiotensin II type 2 receptor antagonist PD123319. Administration of the AT(1) receptor antagonist candesartan reduced the amplitude of swallow-induced peristaltic contractions and both the length and pressure amplitude of baseline high-pressure zone at the esophagogastric junction. Neither swallow-induced axial movements, nor the contraction after transient lower esophageal sphincter relaxations, were influenced by candesartan pretreatment. CONCLUSIONS: The study demonstrates a local RAS in the musculature of the distal esophagus and that Angiotensin II is a potent stimulator of esophageal contractions via the AT(1) receptor. The results suggest that Angiotensin II participates in the physiological control of the human esophageal motor activity.
Keyword
- Aged
- Aged
- 80 and over
- Angiotensin II/*pharmacology
- Angiotensin II Type 1 Receptor Blockers/administration & dosage
- Angiotensinogen/genetics
- Benzimidazoles/administration & dosage
- Esophageal Sphincter
- Lower/*physiology
- Esophagus/*physiology
- Female
- Gene Expression
- Humans
- Male
- Manometry
- Middle Aged
- Muscle Contraction/*drug effects
- Peptidyl-Dipeptidase A/genetics
- Peristalsis/drug effects
- Receptor
- Angiotensin
- Type 1/genetics/metabolism
- Receptor
- Angiotensin
- Type 2/genetics/metabolism
- Renin/genetics/metabolism
- Tetrazoles/administration & dosage
- Vasoconstrictor Agents/*pharmacology
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Casselbrant, Ann ...
-
Edebo, Anders, 1 ...
-
Wennerblom, Joha ...
-
Lönroth, Hans, 1 ...
-
Helander, Herber ...
-
Vieth, M.
-
show more...
-
Lundell, L.
-
Fändriks, Lars, ...
-
show less...
- Articles in the publication
-
Gastroenterology
- By the university
-
University of Gothenburg
-
Karolinska Institutet