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Adrenal incidentalo...
Adrenal incidentaloma - follow-up results from a Swedish prospective study
- Article/chapterEnglish2006
Publisher, publication year, extent ...
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Oxford University Press (OUP),2006
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LIBRIS-ID:oai:gup.ub.gu.se/48383
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https://gup.ub.gu.se/publication/48383URI
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https://doi.org/10.1530/eje.1.02110DOI
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https://lup.lub.lu.se/record/410847URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:1946906URI
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-37623URI
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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OBJECTIVES: To examine the risk of developing adrenal carcinomas and clinically overt hypersecreting tumours during short-term follow-up in patients with adrenal incidentalomas. DESIGN: 229 (98 males and 131 females) patients with adrenal incidentalomas were investigated in a prospective follow-up study (median time 25 months; range 3-108 months). The patients were registered between January 1996 and July 2001 and followed until December 2004. Twenty-seven Swedish hospitals contributed with follow-up results. METHODS: Diagnostic procedures were undertaken according to a protocol including reinvestigation with computed tomography scans after 3-6 months, 15-18 months and 27-30 months, as well as hormonal evaluation at baseline and after 27-30 months of follow-up. Operation was recommended when the incidentaloma size increased or if there was a suspicion of a hypersecreting tumour. RESULTS: The median age at diagnosis of the 229 patients included in the follow-up study was 64 years (range 28-84 years) and the median size of the adrenal incidentalomas when discovered was 2.5 cm (range 1-8 cm). During the follow-up period, an increase in incidentaloma size of > or =0.5 cm was reported in 17 (7.4%) and of > or =1.0 cm was reported in 12 (5.2%) of the 229 patients. A decrease in size was seen in 12 patients (5.2%). A hypersecreting tumour was found in 2% of the hormonally investigated patients: Cushing's syndrome (n = 2) and phaeochromocytoma (n = 1). Eleven patients underwent adrenalectomy, but no cases of primary adrenal malignancy were observed. CONCLUSIONS: Patients with adrenal incidentaloma had a low risk of developing malignancy or hormonal hypersecretion during a short-term follow-up period.
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Jansson, Svante,1948Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences(Swepub:gu)xjanss
(author)
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Juhlin, Claes,1952-Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Avdelningen för kirurgi,Kirurgiska kliniken i Östergötland med verksamhet i Linköping, Norrköping och Motala(Swepub:liu)claju74
(author)
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Steen, Lars
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Thorén, MarjaKarolinska Institutet
(author)
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Wahrenberg, H.
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Valdemarsson, StigLund University,Lunds universitet,Medicin, Lund,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Medicine, Lund,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)med-sva
(author)
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Wängberg, Bo,1953Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences(Swepub:gu)xwanbo
(author)
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Ahrén, BoLund University,Lunds universitet,Medicin, Lund,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Medicine, Lund,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)med-bah
(author)
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Wahrenberg, L
(author)
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Göteborgs universitetInstitutionen för kliniska vetenskaper
(creator_code:org_t)
Related titles
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In:European journal of endocrinology / European Federation of Endocrine Societies: Oxford University Press (OUP)154:3, s. 419-230804-46431479-683X
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In:European Journal of Endocrinology: Oxford University Press (OUP)154:3, s. 419-231479-683X
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Bülow, Birgitta
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Jansson, Svante, ...
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Juhlin, Claes, 1 ...
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Steen, Lars
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Thorén, Marja
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Wahrenberg, H.
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Valdemarsson, St ...
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Wängberg, Bo, 19 ...
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Ahrén, Bo
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Wahrenberg, L
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Endocrinology an ...
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University of Gothenburg
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Lund University
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Karolinska Institutet
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Linköping University