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Proinflammatory act...
Proinflammatory activity of a cecropin-like antibacterial peptide from Helicobacter pylori
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- Bylund, Johan, 1975 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för reumatologi och inflammationsforskning,Institute of Internal Medicine, Dept of Rheumatology and Inflammation Research
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Christophe, T. (author)
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Boulay, F. (author)
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- Nyström, Thomas, 1960 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för cell- och molekylärbiologi,Department of Cell and Molecular Biology
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- Karlsson, Anna, 1967 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för reumatologi och inflammationsforskning,Institute of Internal Medicine, Dept of Rheumatology and Inflammation Research
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- Dahlgren, Claes, 1949 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för reumatologi och inflammationsforskning,Institute of Internal Medicine, Dept of Rheumatology and Inflammation Research
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(creator_code:org_t)
- 2001
- 2001
- English.
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In: Antimicrob Agents Chemother. ; 45:6, s. 1700-4
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Abstract
Subject headings
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- Helicobacter pylori, the bacterial pathogen associated with gastritis and peptic ulcers, is highly successful in establishing infection in the human gastric mucosa, a process typically associated with massive infiltration of inflammatory cells. Colonization of the mucosa is suggested to be facilitated by H. pylori-produced cecropin-like peptides with antibacterial properties, giving the microbe a competitive advantage over other bacteria. We show that a cecropin-like antibacterial peptide from H. pylori, Hp(2-20), not only has a potent bactericidal effect but also induces proinflammatory activities in human neutrophils, e.g., upregulation of integrins (Mac-1), induction of chemotaxis, and activation of the oxygen radical producing NADPH-oxidase. Furthermore, we show that these effects are mediated through binding of Hp(2-20) to the promiscuous, G-protein-linked lipoxin A(4) receptor-formyl peptide-like receptor 1.
Keyword
- Anti-Bacterial Agents/*pharmacology
- Bacterial Proteins/pharmacology
- Helicobacter pylori/*drug effects
- Humans
- Macrophage-1 Antigen/*drug effects
- NADPH Oxidase/metabolism
- Neutrophil Activation/drug effects
- Neutrophils/*drug effects/enzymology
- Peptide Fragments/pharmacology
- Receptors
- Cell Surface/drug effects
- *Receptors
- Formyl Peptide
- *Receptors
- Lipoxin
Publication and Content Type
- ref (subject category)
- art (subject category)
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Bylund, Johan, 1 ...
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Christophe, T.
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Boulay, F.
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Nyström, Thomas, ...
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Karlsson, Anna, ...
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Dahlgren, Claes, ...
- Articles in the publication
- Antimicrob Agent ...
- By the university
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University of Gothenburg