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ATP depletion and c...
ATP depletion and cell death in the neonatal lamb ductus arteriosus
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- Levin, Max, 1969 (author)
- Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory
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Goldbarg, S. (author)
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- Lindqvist, Anders (author)
- Lund University,Lunds universitet,Islet cell physiology,Forskargrupper vid Lunds universitet,Lund University Research Groups
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- Swärd, Karl (author)
- Lund University,Lunds universitet,Cellulär biomekanik,Forskargrupper vid Lunds universitet,Kärlfysiologi,Cellular Biomechanics,Lund University Research Groups,Vascular Physiology
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Roman, C. (author)
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Liu, B. M. (author)
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- Mattsson Hultén, Lillemor, 1951 (author)
- Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory
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- Borén, Jan, 1963 (author)
- Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory
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Clyman, R. I. (author)
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(creator_code:org_t)
- 2005
- 2005
- English.
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In: Pediatr Res. - 0031-3998. ; 57:6, s. 801-805
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Abstract
Subject headings
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- Postnatal constriction of the full-term ductus arteriosus produces cell death and remodeling of the ductus wall. Using a bioluminescence imaging technique, we found that after birth, the lamb ductus develops ATP, glucose, and glycogen depletion in addition to hypoxia. In vitro studies showed that cell death correlates best with ATP depletion and is most marked when both glucose and oxygen are severely depleted; in addition, the degree of ATP depletion found in vivo is sufficient to account for the extensive degree of cell death that occurs after birth. Under hypoxic conditions, the immature ductus is more capable of preserving its ATP supply than the mature ductus as a result of increased glucose availability, glycogen stores, and glucose utilization. However, the immature ductus is just as susceptible as the mature ductus to ATP depletion when glucose supplies are restricted. The extensive degree of cell death that occurs in the newborn ductus after birth is associated primarily with ATP depletion. The increased glycolytic capacity of the immature ductus may enable it to tolerate episodes of hypoxia and nutrient shortage, making it more resistant to developing postnatal cell death and permanent closure.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
Keyword
- Adenosine Triphosphate/*metabolism
- Animals
- Animals
- Newborn
- Anoxia/metabolism/pathology
- *Apoptosis
- Ductus Arteriosus/*cytology/*metabolism
- Fetus/cytology/metabolism
- Glucose/metabolism
- Glycolysis
- Hypoglycemia/metabolism/pathology
- Sheep
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Levin, Max, 1969
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Goldbarg, S.
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Lindqvist, Ander ...
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Swärd, Karl
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Roman, C.
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Liu, B. M.
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show more...
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Mattsson Hultén, ...
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Borén, Jan, 1963
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Clyman, R. I.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Pediatrics
- Articles in the publication
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Pediatr Res
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Pediatric Resear ...
- By the university
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University of Gothenburg
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Lund University