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  • Hägg, Daniel,1974Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,University of Gothenburg,Research Center for Endocrinology and Metabolism, Department of Metabolism and Cardiovascular Research, Göteborg, Sweden (author)

Augmented levels of CD44 in macrophages from atherosclerotic subjects: a possible IL-6-CD44 feedback loop?

  • Article/chapterEnglish2007

Publisher, publication year, extent ...

  • Elsevier BV,2007

Numbers

  • LIBRIS-ID:oai:gup.ub.gu.se/49407
  • https://gup.ub.gu.se/publication/49407URI
  • https://doi.org/10.1016/j.atherosclerosis.2006.03.020DOI
  • https://research.chalmers.se/publication/49407URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-11382URI

Supplementary language notes

  • Language:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • The cell-adhesion molecule CD44 likely participates in atherosclerosis development. We have shown previously that pro-inflammatory cytokines affect CD44 expression. Therefore, this work examined the role of elevated CD44 levels in human macrophages. Macrophages from human atherosclerotic subjects (n=15) showed elevated levels of CD44 transcript and protein (1.5-fold) compared to matched controls (n=15) (P=0.050 and 0.044, respectively). To test whether genetic factors influence CD44 expression, two single nucleotide polymorphisms in the CD44 gene were analyzed but these were not associated with coronary artery disease. We also examined the potential connection between plasma cytokine levels and CD44 expression. In atherosclerotic subjects, elevated CD44 expression correlates (P=0.012) with enhanced macrophage IL-6 secretion (3.13+/-2.5 pg/mL versus 0.32+/-0.16 pg/mL in controls, P=0.021). Additionally, CD44-deficient mice exhibit less circulating IL-6 than wild-type controls (9.8+/-0.7 pg/mL versus 14.3+/-0.7 pg/mL; P=0.032). Furthermore, IL-6 augments CD44 expression in primary human macrophages after 24 h (P=0.038) and 48 h (P=0.015). Taken together, our data show an IL-6-CD44 feedback loop in macrophages. Such a positive feedback loop may aggravate atherosclerosis development.

Subject headings and genre

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  • Sjöberg, Sara,1979Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,University of Gothenburg,Research Center for Endocrinology and Metabolism, Department of Metabolism and Cardiovascular Research, Göteborg, Sweden(Swepub:gu)xsjobs (author)
  • Mattsson Hultén, Lillemor,1951Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory,University of Gothenburg,Wallenberg Laboratory for Cardiovascular Research, Department of Metabolism and Cardiovascular Research, Göteborg, Sweden(Swepub:gu)xmatli (author)
  • Fagerberg, Björn,1943Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Wallenberg Laboratory,Institute of Medicine, Department of Molecular and Clinical Medicine,University of Gothenburg,Wallenberg Laboratory for Cardiovascular Research, Department of Metabolism and Cardiovascular Research, Göteborg, Sweden(Swepub:gu)xfagbj (author)
  • Wiklund, Olov,1943Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Wallenberg Laboratory,Institute of Medicine, Department of Molecular and Clinical Medicine,University of Gothenburg,Wallenberg Laboratory for Cardiovascular Research, Department of Metabolism and Cardiovascular Research, Göteborg, Sweden(Swepub:gu)xwikol (author)
  • Rosengren, Annika,1951Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för akut och kardiovaskulär medicin,Institute of Medicine, Department of Emergeny and Cardiovascular Medicine,University of Gothenburg,Department of Acute and Cardiovascular Medicine, Sahlgrenska Academy, Göteborg University, Göteborg, Sweden(Swepub:gu)xrosan (author)
  • Carlsson, Lena M S,1957Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine(Swepub:gu)xcarle (author)
  • Borén, Jan,1963Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Wallenberglaboratoriet,Institute of Medicine, Department of Molecular and Clinical Medicine,Wallenberg Laboratory,University of Gothenburg,Wallenberg Laboratory for Cardiovascular Research, Department of Metabolism and Cardiovascular Research, Göteborg, Sweden(Swepub:gu)xborej (author)
  • Svensson, Per-Arne,1969Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Wallenberg Laboratory,Institute of Medicine, Department of Molecular and Clinical Medicine,University of Gothenburg,Research Center for Endocrinology and Metabolism, Department of Metabolism and Cardiovascular Research, Göteborg, Sweden / Wallenberg Laboratory for Cardiovascular Research, Department of Metabolism and Cardiovascular Research, Göteborg, Sweden(Swepub:gu)xsvper (author)
  • Krettek, Alexandra,1968Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory,University of Gothenburg,Wallenberg Laboratory for Cardiovascular Research, Department of Metabolism and Cardiovascular Research, Göteborg, Sweden(Swepub:his)krea (author)
  • Göteborgs universitetInstitutionen för medicin, avdelningen för molekylär och klinisk medicin (creator_code:org_t)

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  • In:Atherosclerosis: Elsevier BV190:2, s. 291-70021-91501879-1484

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