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Search: onr:"swepub:oai:gup.ub.gu.se/49413" > A common polymorphi...

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  • Wernstedt, Ingrid,1978Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för kroppssammansättning och metabolism,Institute of Internal Medicine, Dept of Body Composition and Metabolism (author)

A common polymorphism in the interleukin-6 gene promoter is associated with overweight

  • Article/chapterEnglish2004

Publisher, publication year, extent ...

  • 2004

Numbers

  • LIBRIS-ID:oai:gup.ub.gu.se/49413
  • https://gup.ub.gu.se/publication/49413URI

Supplementary language notes

  • Language:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • OBJECTIVE: Human body fat mass is to a large extent genetically determined, but little is known about the susceptibility genes for common obesity. Interleukin-6 (IL-6) suppresses body fat mass in rodents, and IL-6 treatment increases energy expenditure in both rodents and humans. The -174 G/C single-nucleotide polymorphism (SNP) in the IL-6 gene promoter is common in many populations, and -174 C-containing promoters have been found to be weaker enhancers of transcription. Moreover, a SNP at position -572 in the IL-6 promoter has recently been reported to affect transcription. The objective was to investigate the association between the IL-6 gene promoter SNPs and obesity. DESIGN: Trans-sectional association study of IL-6 gene promoter SNPs and indices of obesity. SUBJECTS: Two study populations, the larger one consisting of hypertensive individuals (mean age 57 y, 73% males, n=485) and the other consisting of 20 y younger nonobese healthy females (n=74). MEASUREMENTS: Genotyping for the -174 IL-6 G/C and the -572 G/C SNPs, body mass index (BMI), serum leptin levels, serum IL-6 levels, C-reactive protein, fasting blood glucose and various blood lipids. RESULTS: The common -174 C allele (f(C)=0.46), but not any -572 allele, was associated with higher BMI and higher serum leptin levels in both study populations. In the larger population, there were significant odds ratios for the association of CC (2.13) and GC (1.76) genotypes with overweight (BMI>25 kg/m(2)). Moreover, as the C allele was common, it accounted for a significant population-attributable risk of overweight (12%; CI 2-21%), although its average effect was modest in this sample. CONCLUSION: Genetically determined individual differences in production of IL-6 may be relevant for the regulation of body fat mass.

Subject headings and genre

  • Adult
  • Body Mass Index
  • Female
  • *Genetic Predisposition to Disease
  • Genotype
  • Humans
  • Interleukin-6/blood/*genetics
  • Leptin/blood
  • Male
  • Middle Aged
  • Obesity/*genetics
  • *Polymorphism
  • Genetic
  • *Promoter Regions (Genetics)

Added entries (persons, corporate bodies, meetings, titles ...)

  • Eriksson, Anna-Lena,1971Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin,Institute of Internal Medicine(Swepub:gu)xeannj (author)
  • Berndtsson, Anna,1979Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för kroppssammansättning och metabolism,Institute of Internal Medicine, Dept of Body Composition and Metabolism(Swepub:gu)xbannl (author)
  • Hoffstedt, J (author)
  • Skrtic, Stanko,1970Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för klinisk farmakologi,Institute of Internal Medicine, Dept of Clinical Pharmacology(Swepub:gu)xskrst (author)
  • Hedner, Thomas,1949Gothenburg University,Göteborgs universitet,Institutionen för fysiologi och farmakologi, Avdelningen för farmakologi,Institutionen för invärtesmedicin,Institute of Physiology and Pharmacology, Dept of Pharmacology,Institute of Internal Medicine(Swepub:gu)xhedto (author)
  • Mattsson Hultén, Lillemor,1951Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory(Swepub:gu)xmatli (author)
  • Wiklund, Olov,1943Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory(Swepub:gu)xwikol (author)
  • Ohlsson, Claes,1965Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för internmedicin,Institute of Internal Medicine, Dept of Medicine(Swepub:gu)xohlcl (author)
  • Jansson, John-Olov,1954Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin,Wallenberglaboratoriet,Institute of Internal Medicine,Wallenberg Laboratory(Swepub:gu)xjanjo (author)
  • Göteborgs universitetInstitutionen för invärtesmedicin, Avdelningen för kroppssammansättning och metabolism (creator_code:org_t)

Related titles

  • In:Int J Obes Relat Metab Disord28:10, s. 1272-9

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