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Microalbuminuria and risk factors in type 1 and type 2 diabetic patients
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- Cederholm, Jan (author)
- Uppsala universitet,Allmänmedicin och klinisk epidemiologi
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- Eliasson, Björn, 1959 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för internmedicin,Institute of Internal Medicine, Dept of Medicine
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- Nilsson, Peter (author)
- Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups
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- Weiss, L. (author)
- Gudbjörnsdottir, Soffia, 1962 (author)
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- (creator_code:org_t)
- Elsevier BV, 2005
- 2005
- English.
- In: Diabetes Res Clin Pract. - : Elsevier BV. - 0168-8227 .- 1872-8227. ; 67:3, s. 258-66
- Journal article (peer-reviewed)
Abstract
Subject headings
Close
- A prospective study of normoalbuminuric diabetic patients was performed between 1997 and 2002 on 4097 type 1 and 6513 type 2 diabetic patients from the Swedish National Diabetes Register (NDR); mean study period, 4.6 years. The strongest independent baseline risk factors for the development of microalbuminuria (20-200 microg/min) were elevated HbA(1c) and diabetes duration in both types 1 and 2 diabetic patients. Other risk factors were high BMI, elevated systolic and diastolic BP in type 2 patients, and antihypertensive therapy in type 1 patients. A subsequent larger cross-sectional study in 2002 showed that established microalbuminuria was independently associated with HbA(1c), diabetes duration, systolic BP, BMI, smoking and triglycerides in types 1 and 2 diabetic patients, and also with HDL-cholesterol in type 2 patients. Relatively few types 1 and 2 patients with microalbuminuria achieved treatment targets of HbA(1c) < 6.5% (21-48%), BP < 130/85 mmHg (33-13%), cholesterol < 5 mmol/l (48-46%), triglycerides < 1.7 mmol/l (83-48%) and BMI < 25 kg/m(2) (50-18%), respectively. In conclusion, high HbA(1c), BP and BMI were independent risk factors for the development of microalbuminuria in types 1 and 2 diabetic patients. These risk factors as well as triglycerides, HDL-cholesterol and smoking were independently associated with established microalbuminuria. Treatment targets were achieved by a relatively few patients with microalbuminuria.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Keyword
- Adult
- Albuminuria/*complications
- Blood Pressure
- Body Mass Index
- Cross-Sectional Studies
- Diabetes Mellitus
- Type 1/epidemiology/*urine
- Diabetes Mellitus
- Type 2/epidemiology/*urine
- Diabetic Nephropathies/*epidemiology
- Female
- Hemoglobin A
- Glycosylated/analysis
- Humans
- Hypertension/epidemiology
- Male
- Middle Aged
- Registries
- Regression Analysis
- Risk Factors
- Smoking/epidemiology
- Sweden/epidemiology
- diabetes
- register
- microalbuminuria
- hypertension
- body mass index
- Adult
- MEDICINE
Publication and Content Type
- ref (subject category)
- art (subject category)
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