Search: onr:"swepub:oai:gup.ub.gu.se/49497" >
Long-term use of ni...
Long-term use of nicotine gum is associated with hyperinsulinemia and insulin resistance
-
- Eliasson, Björn, 1959 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin,Institute of Internal Medicine
-
Taskinen, M. R. (author)
-
- Smith, Ulf, 1943 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin,Institute of Internal Medicine
-
(creator_code:org_t)
- 1996
- 1996
- English.
-
In: Circulation. - 0009-7322. ; 94:5, s. 878-81
- Related links:
-
https://gup.ub.gu.se...
Abstract
Subject headings
Close
- BACKGROUND: Insulin sensitivity and cardiovascular risk profile were examined in 20 healthy, nonobese, middle-aged men who were long-term users of nicotine-containing chewing gum and in 20 matched control subjects who did not use nicotine. METHODS AND RESULTS: Long-term use of nicotine-containing chewing gum was associated with insulin resistance and hyperinsulinemia. The degree of insulin sensitivity correlated negatively to the extent of nicotine use measured as plasma cotinine levels. CONCLUSIONS: These findings suggest that nicotine is the major constituent in cigarette smoke that leads to insulin resistance, metabolic abnormalities associated with the insulin resistance syndrome, and increased cardiovascular morbidity. Thus, the use of nicotine replacement therapy during smoking cessation should be transient and limited.
Keyword
- Adult
- C-Peptide/analysis
- Cotinine/blood
- Humans
- Insulin/*blood
- *Insulin Resistance
- Male
- Middle Aged
- Nicotine/*administration & dosage
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database