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Identification of g...
Identification of genes predominantly expressed in human macrophages
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- Svensson, Per Anders, 1959 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för kroppssammansättning och metabolism,Institute of Internal Medicine, Dept of Body Composition and Metabolism,University of Gothenburg
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- Hägg, Daniel, 1974 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för kroppssammansättning och metabolism,Institute of Internal Medicine, Dept of Body Composition and Metabolism,University of Gothenburg
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- Jernås, Margareta, 1961 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för kroppssammansättning och metabolism,Institute of Internal Medicine, Dept of Body Composition and Metabolism,University of Gothenburg
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- Englund, Mikael C. O., 1971 (author)
- Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory,University of Gothenburg
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- Mattsson Hultén, Lillemor, 1951 (author)
- Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory,University of Gothenburg
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- Ohlsson, Bertil, 1954 (author)
- Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory,University of Gothenburg
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- Hulthe, Johannes, 1970 (author)
- Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory,University of Gothenburg
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- Wiklund, Olov, 1943 (author)
- Gothenburg University,Göteborgs universitet,Hjärt-kärlinstitutionen,Wallenberglaboratoriet,Cardiovascular Institute,Wallenberg Laboratory,University of Gothenburg
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- Carlsson, Björn, 1958 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin,Institute of Internal Medicine,University of Gothenburg
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- Fagerberg, Björn, 1943 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för internmedicin,Wallenberglaboratoriet,Institute of Internal Medicine, Dept of Medicine,Wallenberg Laboratory,University of Gothenburg
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- Carlsson, Lena M S, 1957 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för kroppssammansättning och metabolism,Institute of Internal Medicine, Dept of Body Composition and Metabolism,University of Gothenburg
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- Svensson, Per-Arne, 1969 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för internmedicin,Institute of Internal Medicine, Dept of Medicine
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(creator_code:org_t)
- Elsevier BV, 2004
- 2004
- English.
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In: Atherosclerosis. - : Elsevier BV. ; 177, s. 287-290
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Abstract
Subject headings
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- Identification of cell and tissue specific genes may provide novel insights to signaling systems and functions. Macrophages play a key role in many diseases including atherosclerosis. Using DNA microarrays we compared the expression of approximately 10,000 genes in 56 human tissues and identified 23 genes with predominant expression in macrophages. The identified genes include both genes known to be macrophage specific and genes previously not well described in this cell type. Tissue distribution of two genes, liver X receptor (LXR) alpha and interleukin-1 receptor antagonist (IL1RN), was verified by real-time RT-PCR. We conclude that comparison of expression profiles from a large number of tissues can be used to identify genes that are predominantly expressed in certain tissues. Identification of novel macrophage specific genes may increase our understanding of the role of this cell in different diseases.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine (hsv//eng)
Keyword
- DNA-Binding Proteins
- Humans
- Interleukin 1 Receptor Antagonist Protein
- Macrophages/chemistry/*physiology
- Oligonucleotide Array Sequence Analysis
- Receptors
- Cytoplasmic and Nuclear/*genetics
- Sialoglycoproteins/*genetics
- Tissue Distribution
- Oligonucleotide Array Sequence Analysis
- Atherosclerosis
- DNA microarray
- Human
- IL1RN
- Macrophages
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Svensson, Per An ...
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Hägg, Daniel, 19 ...
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Jernås, Margaret ...
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Englund, Mikael ...
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Mattsson Hultén, ...
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Ohlsson, Bertil, ...
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Hulthe, Johannes ...
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Wiklund, Olov, 1 ...
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Carlsson, Björn, ...
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Fagerberg, Björn ...
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Carlsson, Lena M ...
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Svensson, Per-Ar ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
- Articles in the publication
- Atherosclerosis
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Atherosclerosis
- By the university
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University of Gothenburg
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Chalmers University of Technology