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The reciprocal asso...
The reciprocal association of adipocytokines with insulin resistance and C-reactive protein in clinically healthy men
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- Behre, Carl Johan, 1968 (author)
- Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory
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- Fagerberg, Björn, 1943 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för internmedicin,Wallenberglaboratoriet,Institute of Internal Medicine, Dept of Medicine,Wallenberg Laboratory
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- Mattsson Hultén, Lillemor, 1951 (author)
- Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory
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- Hulthe, Johannes, 1970 (author)
- Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory
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(creator_code:org_t)
- 2005
- 2005
- English.
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In: Metabolism. - 0026-0495. ; 54:4, s. 439-44
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Abstract
Subject headings
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- In experimental models, adiponectin improves and tumor necrosis factor alpha (TNF- alpha ) impairs insulin action, and the expression of these adipocytokines seems to have a reciprocal regulation. The aim was to examine whether in a cross-sectional study, associations supporting this concept may be found in 58-year-old clinically healthy men, and also the relation to C-reactive protein (CRP). In 102 men, euglycemic hyperinsulinemic clamp was used to assess glucose infusion rate (GIR). Total body fat (dual-energy x-ray absorptiometry), plasma adiponectin (radioimmunoassay), TNF-alpha , and CRP (enzyme-linked immunosorbent assay) were measured. Adiponectin correlated positively to GIR (r=0.33, P<.001) and negatively to total fat mass (r=-0.29, P=.004), whereas TNF- alpha showed reverse associations (r=-0.31, P<.01, and r=0.31, P<.01). Adiponectin and TNF- alpha were negatively correlated (-0.28, P=.006). An interaction term (TNF- alpha /adiponectin ratio) and body fat together explained 31.3% (P<.001) in GIR variability. The odds ratio for having insulin resistance was 9.3 (95% CI, 2.2-38.9) in subjects with TNF-alpha values above and adiponectin levels below the median, as compared to subjects with TNF- alpha values below and adiponectin levels above the median. Total fat and TNF-alpha , but not adiponectin, were significantly associated with log CRP (R2=20%, P<.001). In conclusion, this study in man showed that plasma adiponectin and TNF-alpha were independently and reversely associated with insulin resistance. C-reactive protein levels were related to TNF-alpha and obesity.
Keyword
- Adiponectin
- Adipose Tissue
- Body Composition
- C-Reactive Protein/*analysis
- Cross-Sectional Studies
- Densitometry
- X-Ray
- Glucose Clamp Technique
- Humans
- Insulin Resistance/*physiology
- Intercellular Signaling Peptides and Proteins/*blood
- Male
- Middle Aged
- Obesity/blood
- Odds Ratio
- Tumor Necrosis Factor-alpha/*analysis
Publication and Content Type
- ref (subject category)
- art (subject category)
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