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A new combined mult...
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Adiels, Martin,1976Gothenburg University,Göteborgs universitet,Institutionen för matematiska vetenskaper,Department of Mathematical Sciences,University of Gothenburg,Chalmers tekniska högskola,Chalmers University of Technology
(author)
A new combined multicompartmental model for apolipoprotein B-100 and triglyceride metabolism in VLDL subfractions
- Article/chapterEnglish2005
Publisher, publication year, extent ...
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LIBRIS-ID:oai:gup.ub.gu.se/50307
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https://gup.ub.gu.se/publication/50307URI
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https://doi.org/10.1194/jlr.M400108-JLR200DOI
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https://research.chalmers.se/publication/50307URI
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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The use of stable isotopes in conjunction with compartmental modeling analysis has greatly facilitated studies of the metabolism of the apolipoprotein B (apoB)-containing lipoproteins in humans. The aim of this study was to develop a multicompartment model that allows us to simultaneously determine the kinetics of apoB and triglyceride (TG) in VLDL(1) and VLDL(2) after a bolus injection of [(2)H(3)]leucine and [(2)H(5)]glycerol and to follow the catabolism and transfer of the lipoprotein particles. Here, we describe the model and present the results of its application in a fasting steady-state situation in 17 subjects with lipid values representative of a Western population. Analysis of the correlations showed that plasma TG was determined by the VLDL(1) and VLDL(2) apoB and TG fractional catabolic rate. Furthermore, the model showed a linear correlation between VLDL(1) TG and apoB production. A novel observation was that VLDL TG entered the circulation within 21 min after its synthesis, whereas VLDL apoB entered the circulation after 33 min. These observations are consistent with a sequential assembly model of VLDL and suggest that the TG is added to a primordial apoB-containing particle in the liver.
Subject headings and genre
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Apolipoprotein B-100
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Apolipoproteins B/biosynthesis/*metabolism
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Deuterium/administration & dosage/metabolism
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Glycerol/administration & dosage/metabolism
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Humans
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Kinetics
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Leucine/administration & dosage/metabolism
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Lipoproteins
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VLDL/biosynthesis/*metabolism
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Models
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Biological
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Protein Transport
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Triglycerides/biosynthesis/*metabolism
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Triglycerides/biosynthesis/*metabolism
Added entries (persons, corporate bodies, meetings, titles ...)
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Packard, C.
(author)
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Caslake, M. J.
(author)
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Stewart, P.
(author)
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Soro, A.
(author)
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Westerbacka, J.
(author)
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Wennberg, Bernt,1961Gothenburg University,Göteborgs universitet,Institutionen för matematiska vetenskaper,Department of Mathematical Sciences,Chalmers tekniska högskola,Chalmers University of Technology,University of Gothenburg(Swepub:cth)wennberg
(author)
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Olofsson, Sven-Olof,1947Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory,University of Gothenburg(Swepub:gu)xolosv
(author)
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Taskinen, M. R.
(author)
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Borén, Jan,1963Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory,University of Gothenburg(Swepub:gu)xborej
(author)
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Göteborgs universitetInstitutionen för matematiska vetenskaper
(creator_code:org_t)
Related titles
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In:J Lipid Res46:1, s. 58-670022-22751539-7262
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Adiels, Martin, ...
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Packard, C.
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Caslake, M. J.
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Stewart, P.
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Soro, A.
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Westerbacka, J.
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Wennberg, Bernt, ...
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Taskinen, M. R.
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Borén, Jan, 1963
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J Lipid Res
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University of Gothenburg
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Chalmers University of Technology