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High local concentr...
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Rotter Sopasakis, Victoria,1972Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för internmedicin,Institute of Internal Medicine, Dept of Medicine
(author)
High local concentrations and effects on differentiation implicate interleukin-6 as a paracrine regulator
- Article/chapterEnglish2004
Publisher, publication year, extent ...
Numbers
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LIBRIS-ID:oai:gup.ub.gu.se/50380
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https://gup.ub.gu.se/publication/50380URI
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Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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OBJECTIVE: To examine the possibility that interleukin-6 (IL-6) can act as a paracrine regulator in adipose tissue by examining effects on adipogenic genes and measuring interstitial IL-6 concentrations in situ. RESEARCH METHODS AND PROCEDURES: Circulating and interstitial IL-6 concentrations in abdominal and femoral adipose tissue were measured using the calibrated microdialysis technique in 20 healthy male subjects. The effects of adipose cell enlargement on gene expression and IL-6 secretion were examined, as well as the effect of IL-6 in vitro on gene expression of adiponectin and other markers of adipocyte differentiation. RESULTS: The IL-6 concentration in the interstitial fluid was approximately 100-fold higher than that in plasma, suggesting that IL-6 may be a paracrine regulator of adipose tissue. This was further supported by the finding that adding IL-6 in vitro at similar concentrations down-regulated the expression of adiponectin, aP2, and PPARgamma-2 in cultured human adipose tissue. In addition, gene expression and release of IL-6, both in vivo and in vitro, correlated with adipose cell size. DISCUSSION: These data suggest that IL-6 may be a paracrine regulator of adipose tissue. Furthermore, increased adipose tissue production of IL-6 after hypertrophic enlargement of the adipose cells may detrimentally affect systemic insulin action by inducing adipose tissue dysfunction with impaired differentiation of the pre-adipocytes and/or adipocytes and lower adiponectin.
Subject headings and genre
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Abdomen
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Adipocytes/*cytology
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Adiponectin
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Adipose Tissue/chemistry/*physiology
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Adult
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Cell Differentiation/*drug effects/genetics
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Cell Size
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Femur
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Gene Expression/drug effects
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Humans
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*Intercellular Signaling Peptides and Proteins
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Interleukin-6/genetics/pharmacology/*physiology
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Male
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Microdialysis
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Middle Aged
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Proteins/genetics
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Receptors
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Cytoplasmic and Nuclear/genetics
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Transcription Factors/genetics
Added entries (persons, corporate bodies, meetings, titles ...)
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Sandqvist, Madelene,1974Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för internmedicin,Institute of Internal Medicine, Dept of Medicine(Swepub:gu)xsamad
(author)
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Gustafson, Birgit,1951Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för internmedicin,Institute of Internal Medicine, Dept of Medicine(Swepub:gu)xgustb
(author)
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Hammarstedt, Ann,1975Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för internmedicin,Institute of Internal Medicine, Dept of Medicine(Swepub:gu)xhaman
(author)
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Schmelz, M.
(author)
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Yang, Xiao Lin,1955Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för internmedicin,Institute of Internal Medicine, Dept of Medicine(Swepub:gu)xyanxi
(author)
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Jansson, Per-Anders,1961Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för internmedicin,Institute of Internal Medicine, Dept of Medicine(Swepub:gu)xjansp
(author)
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Smith, Ulf,1943Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för internmedicin,Institute of Internal Medicine, Dept of Medicine(Swepub:gu)xsmiul
(author)
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Göteborgs universitetInstitutionen för invärtesmedicin, Avdelningen för internmedicin
(creator_code:org_t)
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In:Obes Res12:3, s. 454-601071-7323
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