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Cytokine release from adipose tissue of nonobese individuals
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- Rotter Sopasakis, Victoria, 1972 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för internmedicin,Institute of Internal Medicine, Dept of Medicine
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- Nagaev, Ivan, 1962 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för internmedicin,Institute of Internal Medicine, Dept of Medicine
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- Smith, Ulf, 1943 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för internmedicin,Institute of Internal Medicine, Dept of Medicine
- (creator_code:org_t)
- 2005-05-24
- 2005
- English.
- In: Int J Obes (Lond). - : Springer Science and Business Media LLC. - 0307-0565. ; 29:9, s. 1144-7
- Journal article (peer-reviewed)
Abstract
Subject headings
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- Explants of human adipose tissue from nonobese subjects were cultured for 24 h with or without the presence of 20 ng/ml TNFalpha. Gene expression and/or medium concentrations of interleukin (IL)-1beta, IL-1 receptor antagonist (IL-1 RA), TNFalpha, IL-6, IL-8, resistin, PAI-1 and leptin were analysed. TNFalpha increased the mRNA levels of TNFalpha itself as well as IL-6, IL-8, IL-1beta and PAI-1, but not leptin. The medium concentrations of IL-1 RA, IL-6 and IL-8 were markedly increased by TNFalpha while no measurable release of TNFalpha, resistin or IL-1beta to the medium was found. Thus, human adipose tissue from nonobese individuals releases substantial amounts of IL-6, IL-8 and IL-1 RA and the gene expression of these cytokines, like that of IL-1beta and PAI-1, is regulated by TNFalpha. However, since neither TNFalpha, resistin or IL-1beta was found in the culture medium, such a regulatory effect by TNFalpha on adipose tissue in vivo is likely to be mediated through a paracrine mechanism where invaded inflammatory cells may play a critical role.
Keyword
- Adipose Tissue/*metabolism
- Cytokines/*analysis
- Female
- Gene Expression Regulation
- Humans
- Interleukin-1/analysis
- Interleukin-6/analysis
- Interleukin-8/analysis
- Leptin/analysis
- Male
- Middle Aged
- Plasminogen Activator Inhibitor 1/analysis
- RNA
- Messenger/analysis
- Receptors
- Interleukin-1/antagonists & inhibitors
- Resistin/analysis
- Tissue Culture Techniques/methods
- Tumor Necrosis Factor-alpha/analysis
Publication and Content Type
- ref (subject category)
- art (subject category)
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