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Cytokine release fr...
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Rotter Sopasakis, Victoria,1972Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för internmedicin,Institute of Internal Medicine, Dept of Medicine
(author)
Cytokine release from adipose tissue of nonobese individuals
- Article/chapterEnglish2005
Publisher, publication year, extent ...
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2005-05-24
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Springer Science and Business Media LLC,2005
Numbers
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LIBRIS-ID:oai:gup.ub.gu.se/50414
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https://gup.ub.gu.se/publication/50414URI
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https://doi.org/10.1038/sj.ijo.0803002DOI
Supplementary language notes
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Explants of human adipose tissue from nonobese subjects were cultured for 24 h with or without the presence of 20 ng/ml TNFalpha. Gene expression and/or medium concentrations of interleukin (IL)-1beta, IL-1 receptor antagonist (IL-1 RA), TNFalpha, IL-6, IL-8, resistin, PAI-1 and leptin were analysed. TNFalpha increased the mRNA levels of TNFalpha itself as well as IL-6, IL-8, IL-1beta and PAI-1, but not leptin. The medium concentrations of IL-1 RA, IL-6 and IL-8 were markedly increased by TNFalpha while no measurable release of TNFalpha, resistin or IL-1beta to the medium was found. Thus, human adipose tissue from nonobese individuals releases substantial amounts of IL-6, IL-8 and IL-1 RA and the gene expression of these cytokines, like that of IL-1beta and PAI-1, is regulated by TNFalpha. However, since neither TNFalpha, resistin or IL-1beta was found in the culture medium, such a regulatory effect by TNFalpha on adipose tissue in vivo is likely to be mediated through a paracrine mechanism where invaded inflammatory cells may play a critical role.
Subject headings and genre
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Adipose Tissue/*metabolism
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Cytokines/*analysis
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Female
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Gene Expression Regulation
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Humans
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Interleukin-1/analysis
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Interleukin-6/analysis
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Interleukin-8/analysis
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Leptin/analysis
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Male
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Middle Aged
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Plasminogen Activator Inhibitor 1/analysis
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RNA
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Messenger/analysis
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Receptors
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Interleukin-1/antagonists & inhibitors
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Resistin/analysis
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Tissue Culture Techniques/methods
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Tumor Necrosis Factor-alpha/analysis
Added entries (persons, corporate bodies, meetings, titles ...)
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Nagaev, Ivan,1962Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för internmedicin,Institute of Internal Medicine, Dept of Medicine(Swepub:gu)xnagiv
(author)
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Smith, Ulf,1943Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för internmedicin,Institute of Internal Medicine, Dept of Medicine(Swepub:gu)xsmiul
(author)
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Göteborgs universitetInstitutionen för invärtesmedicin, Avdelningen för internmedicin
(creator_code:org_t)
Related titles
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