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  • Takemoto, MinoruKarolinska Institutet (author)

Large-scale identification of genes implicated in kidney glomerulus development and function.

  • Article/chapterEnglish2006

Publisher, publication year, extent ...

  • 2006-02-23
  • Wiley,2006

Numbers

  • LIBRIS-ID:oai:gup.ub.gu.se/50999
  • https://gup.ub.gu.se/publication/50999URI
  • https://doi.org/10.1038/sj.emboj.7601014DOI
  • https://research.chalmers.se/publication/50999URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:1935927URI

Supplementary language notes

  • Language:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • To advance our understanding of development, function and diseases in the kidney glomerulus, we have established and large-scale sequenced cDNA libraries from mouse glomeruli at different stages of development, resulting in a catalogue of 6053 different genes. The glomerular cDNA clones were arrayed and hybridized against a series of labeled targets from isolated glomeruli, non-glomerular kidney tissue, FACS-sorted podocytes and brain capillaries, which identified over 300 glomerular cell-enriched transcripts, some of which were further sublocalized to podocytes, mesangial cells and juxtaglomerular cells by in situ hybridization. For the earliest podocyte marker identified, Foxc2, knockout mice were used to analyze the role of this protein during glomerular development. We show that Foxc2 controls the expression of a distinct set of podocyte genes involved in podocyte differentiation and glomerular basement membrane maturation. The primary podocyte defects also cause abnormal differentiation and organization of the glomerular vascular cells. We surmise that studies on the other novel glomerulus-enriched transcripts identified in this study will provide new insight into glomerular development and pathomechanisms of disease.

Subject headings and genre

  • Animals
  • Basement Membrane
  • cytology
  • metabolism
  • Brain
  • cytology
  • metabolism
  • Cell Differentiation
  • Female
  • Forkhead Transcription Factors
  • genetics
  • physiology
  • Gene Expression Profiling
  • Gene Expression Regulation
  • Developmental
  • Gene Library
  • Glomerular Mesangium
  • cytology
  • metabolism
  • In Situ Hybridization
  • Integrases
  • metabolism
  • Kidney Glomerulus
  • cytology
  • physiology
  • Male
  • Mice
  • Mice
  • Inbred ICR
  • Mice
  • Knockout
  • Nephrons
  • cytology
  • metabolism
  • Oligonucleotide Array Sequence Analysis
  • Podocytes
  • cytology
  • metabolism
  • metabolism

Added entries (persons, corporate bodies, meetings, titles ...)

  • He, LiqunKarolinska Institutet (author)
  • Norlin, JennyKarolinska Institutet (author)
  • Patrakka, JaakkoKarolinska Institutet (author)
  • Xiao, ZhijieKarolinska Institutet (author)
  • Petrova, TatianaHelsingin Yliopisto,University of Helsinki (author)
  • Bondjers, Cecilia,1974Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi,Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology,University of Gothenburg(Swepub:gu)xbonce (author)
  • Asp, Julia,1973Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för patologi,Institute of Biomedicine, Department of Pathology,University of Gothenburg(Swepub:gu)xaspjd (author)
  • Wallgard, ElisabetKarolinska Institutet (author)
  • Sun, Ying,1955Karolinska Institutet (author)
  • Samuelsson, Tore,1951Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi,Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology,University of Gothenburg(Swepub:gu)xsamto (author)
  • Mostad, Petter,1964Gothenburg University,Göteborgs universitet,Institutionen för matematiska vetenskaper, matematisk statistik,Department of Mathematical Sciences, Mathematical Statistics,Chalmers tekniska högskola,Chalmers University of Technology,University of Gothenburg(Swepub:cth)mostad (author)
  • Lundin, Samuel B,1970Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi,Institute of Biomedicine, Department of Microbiology and Immunology,University of Gothenburg(Swepub:gu)xlusam (author)
  • Miura, NaoyukiHamamatsu University (author)
  • Sado, YoshikazuShigei Medical Research Institute (author)
  • Alitalo, KariHelsingin Yliopisto,University of Helsinki (author)
  • Quaggin, Susan EUniversity of Toronto (author)
  • Tryggvason, KarlKarolinska Institutet (author)
  • Betsholtz, Christer,1959Karolinska Institutet (author)
  • Karolinska InstitutetHelsingin Yliopisto (creator_code:org_t)

Related titles

  • In:The EMBO journal: Wiley25:5, s. 1160-740261-41891460-2075

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