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Neocortical neuroge...
Neocortical neurogenesis in humans is restricted to development.
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Bhardwaj, R. D. (author)
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- Curtis, Maurice A (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap och rehabilitering,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience and Rehabilitation
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- Spalding, K. L. (author)
- Karolinska Institutet
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Buchholz, B. A. (author)
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Fink, David (author)
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- Björk-Eriksson, Thomas, 1960 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences
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- Nordborg, Claes, 1946 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för patologi,Institute of Biomedicine, Department of Pathology
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Gage, Fred H (author)
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- Druid, H. (author)
- Karolinska Institutet
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- Eriksson, Peter S, 1959 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap och rehabilitering,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience and Rehabilitation
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- Frisén, Jonas (author)
- Karolinska Institutet
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(creator_code:org_t)
- 2006-08-15
- 2006
- English.
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In: Proceedings of the National Academy of Sciences of the United States of America. - : Proceedings of the National Academy of Sciences. - 0027-8424. ; 103:33, s. 12564-8
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Abstract
Subject headings
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- Stem cells generate neurons in discrete regions in the postnatal mammalian brain. However, the extent of neurogenesis in the adult human brain has been difficult to establish. We have taken advantage of the integration of (14)C, generated by nuclear bomb tests during the Cold War, in DNA to establish the age of neurons in the major areas of the human cerebral neocortex. Together with the analysis of the neocortex from patients who received BrdU, which integrates in the DNA of dividing cells, our results demonstrate that, whereas nonneuronal cells turn over, neurons in the human cerebral neocortex are not generated in adulthood at detectable levels but are generated perinatally.
Keyword
- Aged
- Aged
- 80 and over
- Aging
- physiology
- Animals
- Antimetabolites
- metabolism
- Atmosphere
- Autopsy
- Bromodeoxyuridine
- metabolism
- Carbon Radioisotopes
- metabolism
- Humans
- Middle Aged
- Neocortex
- cytology
- embryology
- growth & development
- Nuclear Warfare
- Stem Cells
- cytology
- physiology
- Time Factors
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Bhardwaj, R. D.
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Curtis, Maurice ...
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Spalding, K. L.
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Buchholz, B. A.
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Fink, David
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Björk-Eriksson, ...
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show more...
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Nordborg, Claes, ...
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Gage, Fred H
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Druid, H.
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Eriksson, Peter ...
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Frisén, Jonas
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show less...
- Articles in the publication
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Proceedings of t ...
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Proceedings of t ...
- By the university
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University of Gothenburg
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Karolinska Institutet