Search: onr:"swepub:oai:gup.ub.gu.se/51532" >
Accelerated acute r...
Accelerated acute rejection of the intestinal graft in CD28-deficient mice.
-
Dindelegan, G. (author)
-
- Oltean, Mihai, 1976 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences
-
- Kurlberg, Göran, 1947 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences
-
show more...
-
- Lycke, Nils Y, 1954 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi,Institute of Biomedicine, Department of Microbiology and Immunology
-
- Nilsson, Ola, 1957 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för patologi,Institute of Biomedicine, Department of Pathology
-
- Olausson, Michael, 1956 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences
-
show less...
-
(creator_code:org_t)
- Elsevier BV, 2007
- 2007
- English.
-
In: Transplantation proceedings. - : Elsevier BV. - 0041-1345. ; 37:1, s. 82-6
- Related links:
-
https://gup.ub.gu.se...
-
show more...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- OBJECTIVE: Multiple in vivo studies have shown that the pace and severity of graft rejection is little or not at all changed by deleting CD28 molecules in the recipient. These findings contrast with the effects of monoclonal antibody therapy aimed the same costimulatory target. The objective of the present study was to evaluate how the acute rejection process is affected in CD28-deficient mice using a fully allogeneic, highly immunologically reactive transplant model. METHODS: Heterotopic vascularized small bowel transplants were performed in 24 recipient mice divided into 4 groups: 2 wild-type and 2 knockout groups. Each group consisted of 5 to 7 animals in which BalbC mice were used as intestinal donors to either wild-type C57BL6 or C57BL6 background CD28-deficient recipient mice. Selected endpoints were 3 and 6 postoperative days (POD). Intestinal rejection was evaluated by mucosal laser Doppler flowmetry (expressed in perfusion units) and histology (expressed in rejection grades). RESULTS: Acute rejection occurred in both wild-type and CD28-deficient groups. At POD 3, no significant difference was noted between groups in terms of mucosal perfusion and histology. At POD 6, significant differences in graft mucosal perfusion and histology revealed a more aggressive rejection in the CD28-deficient group compared to the wild-type group. CONCLUSIONS: The present study showed that the severity of intestinal graft rejection responses was amplified by deleting CD28 molecules. Together with data from other studies, these results suggest a different pattern of distribution and/or activation of CD28/B7 receptors in various organs.
Keyword
- Acute Disease
- Animals
- Antigens
- CD28
- genetics
- Gene Deletion
- Graft Rejection
- genetics
- immunology
- pathology
- Intestinal Mucosa
- pathology
- transplantation
- Intestine
- Small
- parasitology
- transplantation
- Male
- Mice
- Mice
- Inbred BALB C
- Mice
- Inbred C57BL
- Mice
- Knockout
- Microcirculation
- immunology
- pathology
- Transplantation
- Homologous
- immunology
- pathology
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Dindelegan, G.
-
Oltean, Mihai, 1 ...
-
Kurlberg, Göran, ...
-
Lycke, Nils Y, 1 ...
-
Nilsson, Ola, 19 ...
-
Olausson, Michae ...
- Articles in the publication
-
Transplantation ...
- By the university
-
University of Gothenburg