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Patient perception ...
Patient perception of the effect of treatment with candesartan in heart failure. Results of the candesartan in heart failure: assessment of reduction in mortality and morbidity (CHARM) programme
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O'Meara, E. (author)
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Lewis, E. (author)
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Granger, C. (author)
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Dunlap, M. E. (author)
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McKelvie, R. S. (author)
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Probstfield, J. L. (author)
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Young, J. B. (author)
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Michelson, E. L. (author)
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- Ostergren, J. (author)
- Karolinska Institutet
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Carlsson, J. (author)
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Olofsson, B. (author)
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McMurray, J. (author)
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Yusuf, S. (author)
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- Swedberg, Karl, 1944 (author)
- Gothenburg University,Göteborgs universitet,Hjärt-kärlinstitutionen,Cardiovascular Institute
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Pfeffer, M. A. (author)
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(creator_code:org_t)
- 2005-05-28
- 2005
- English.
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In: European journal of heart failure. - : Wiley. - 1388-9842. ; 7:4, s. 650-6
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Abstract
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- AIMS: To evaluate the effect of the angiotensin receptor blocker candesartan on patients' perception of symptoms, using the McMaster Overall treatment evaluation (OTE), in a broad spectrum of patients with chronic heart failure (CHF). METHODS AND RESULTS: Patients with symptomatic CHF, randomised in the CHARM Programme in North America (n=2498), were studied. OTE was assessed at baseline, at 6, 14 and 26 months and the patient's final or closing visit. Patient's status was classified as "improved (score +1 to +7)", "unchanged (score 0)" or "deteriorated (score -1 to -7)" at the end of the study compared to baseline. Both a simple "last visit carried forward" (LVCF) analysis and "worst rank carried forward" (WRCF) analysis (where patients who died were allocated the worst OTE score) were used. In the LVCF analysis, compared to placebo, more candesartan patients improved (37.7% versus 33.5%) and fewer worsened (10.8% versus 12.0%) in OTE (p=0.017). The WRCF analysis also showed better overall OTE scores with candesartan compared to placebo (p=0.029). There was no heterogeneity in the response to candesartan between the CHARM component trials or across four exploratory sub-groups (age, sex, NYHA class and beta-blocker). CONCLUSIONS: Candesartan was shown to be better than placebo, when using the McMaster OTE to measure patient perception of treatment. More patients treated with candesartan reported improvement and fewer reported deterioration. This benefit was obtained when candesartan was added to extensive background therapy and is consistent with the benefits of candesartan on NYHA class, hospital admission for worsening heart failure and mortality.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Keyword
- Aged
- Angiotensin II Type 1 Receptor Blockers/*therapeutic use
- Benzimidazoles/*therapeutic use
- Female
- Health Status Indicators
- Heart Failure
- Congestive/*drug therapy
- Humans
- Male
- Patient Satisfaction
- *Quality of Life
- Questionnaires
- Randomized Controlled Trials
- Tetrazoles/*therapeutic use
- Treatment Outcome
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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O'Meara, E.
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Lewis, E.
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Granger, C.
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Dunlap, M. E.
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McKelvie, R. S.
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Probstfield, J. ...
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show more...
-
Young, J. B.
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Michelson, E. L.
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Ostergren, J.
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Carlsson, J.
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Olofsson, B.
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McMurray, J.
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Yusuf, S.
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Swedberg, Karl, ...
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Pfeffer, M. A.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
- Articles in the publication
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European journal ...
- By the university
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University of Gothenburg
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Karolinska Institutet