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Quantitative proteo...
Quantitative proteomics analysis of the secretory pathway.
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Gilchrist, Annalyn (author)
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Au, Catherine E (author)
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- Hiding, Johan, 1976 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk genetik och klinisk genetik,Institute of Biomedicine, Department of Medical and Clinical Genetics
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Bell, Alexander W (author)
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- Fernandez-Rodriguez, Julia, 1965 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk genetik och klinisk genetik,Institute of Biomedicine, Department of Medical and Clinical Genetics
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Lesimple, Souad (author)
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Nagaya, Hisao (author)
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Roy, Line (author)
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Gosline, Sara J C (author)
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Hallett, Michael (author)
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Paiement, Jacques (author)
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Kearney, Robert E (author)
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- Nilsson, Tommy, 1960 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk genetik och klinisk genetik,Institute of Biomedicine, Department of Medical and Clinical Genetics
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Bergeron, John JM (author)
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(creator_code:org_t)
- Elsevier BV, 2006
- 2006
- English.
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In: Cell. - : Elsevier BV. - 0092-8674. ; 127:6, s. 1265-81
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http://www.cell.com/...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
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- We report more than 1400 proteins of the secretory-pathway proteome and provide spatial information on the relative presence of each protein in the rough and smooth ER Golgi cisternae and Golgi-derived COPI vesicles. The data support a role for COPI vesicles in recycling and cisternal maturation, showing that Golgi-resident proteins are present at a higher concentration than secretory cargo. Of the 1400 proteins, 345 were identified as previously uncharacterized. Of these, 230 had their subcellular location deduced by proteomics. This study provides a comprehensive catalog of the ER and Golgi proteomes with insight into their identity and function.
Keyword
- Animals
- Coat Protein Complex I
- Endoplasmic Reticulum
- chemistry
- Golgi Apparatus
- chemistry
- Liver
- chemistry
- cytology
- Protein Transport
- Proteins
- analysis
- isolation & purification
- Proteomics
- Rats
- SNARE Proteins
- isolation & purification
- Tandem Mass Spectrometry
- rab GTP-Binding Proteins
- genetics
- isolation & purification
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Gilchrist, Annal ...
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Au, Catherine E
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Hiding, Johan, 1 ...
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Bell, Alexander ...
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Fernandez-Rodrig ...
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Lesimple, Souad
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show more...
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Nagaya, Hisao
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Roy, Line
-
Gosline, Sara J ...
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Hallett, Michael
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Paiement, Jacque ...
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Kearney, Robert ...
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Nilsson, Tommy, ...
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Bergeron, John J ...
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Cell
- By the university
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University of Gothenburg