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Detection of antibo...
Detection of antibodies to toxin-coregulated pili in sera from cholera patients
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Attridge, Stephen, 1951 (author)
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- Wallerström, Gun, 1942 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicinsk mikrobiologi och immunologi,Institute of Medical Microbiology/Immunology
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Qadri, Firdausi (author)
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- Svennerholm, Ann-Mari, 1947 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicinsk mikrobiologi och immunologi,Institute of Medical Microbiology/Immunology
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(creator_code:org_t)
- 2004
- 2004
- English.
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In: Infect Immun. ; 72:3, s. 1824-7
- Related links:
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Monoclonal antibodies (MAbs) were prepared against toxin-coregulated pili (TCP) isolated from Vibrio cholerae O1 El Tor. Despite their limited bactericidal potential, two MAbs were able to mediate biotype-specific protection against experimental cholera in infant mice. These MAbs were used in immunoblotting studies to assess seroconversion to El Tor TCP following cholera. Clear anti-pilus responses were observed in five of nine patients.
Keyword
- Animals
- Antibodies
- Bacterial/administration & dosage/*blood
- Antibodies
- Monoclonal/administration & dosage
- Antibody Specificity
- Antigens
- Bacterial
- Bacterial Toxins/antagonists & inhibitors/*immunology
- Cholera/*immunology/microbiology/prevention & control
- Cholera Vaccines/administration & dosage
- Fimbriae
- Bacterial/*immunology
- Humans
- Mice
- Vibrio cholerae O1/*immunology
Publication and Content Type
- ref (subject category)
- art (subject category)
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