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Differential mechan...
Differential mechanisms for T lymphocyte recruitment in normal and neoplastic human gastric mucosa
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- Enarsson, Karin, 1975 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi,Institute of Biomedicine, Department of Microbiology and Immunology
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- Johnsson, Erik, 1966 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för gastrokirurgisk forskning och utbildning,Institute of Clinical Sciences, Department of Gastrosurgical Research and Education
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- Lindholm, Catharina, 1967 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research
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- Lundgren, Anna, 1974 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi,Institute of Biomedicine, Department of Microbiology and Immunology
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- Pan-Hammarström, Q. (author)
- Karolinska Institutet
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- Strömberg, Erika, 1974 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi,Institute of Biomedicine, Department of Microbiology and Immunology
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- Bergin, Philip, 1975 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi,Institute of Biomedicine, Department of Microbiology and Immunology
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- Baunge, E. L. (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi,Institute of Biomedicine, Department of Microbiology and Immunology
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- Svennerholm, Ann-Mari, 1947 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi,Institute of Biomedicine, Department of Microbiology and Immunology
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- Quiding-Järbrink, Marianne, 1964 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi,Institute of Biomedicine, Department of Microbiology and Immunology
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(creator_code:org_t)
- Elsevier BV, 2006
- 2006
- English.
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In: Clin Immunol. - : Elsevier BV. ; 118:1, s. 24-34
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Abstract
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- Worldwide, gastric adenocarcinoma (GC) is the second most common cause of death from malignant disease. The reason why immune responses are unable to clear the tumour is not fully understood, although aberrant lymphocyte recruitment to the tumour site might be one factor. Therefore, we investigated the homing phenotype of mucosal T lymphocytes in GC, compared to tumour-free mucosa. We could detect significantly decreased frequencies of mucosal homing alpha4beta7+ T cells in the tumour tissues and increased frequencies of L-selectin+ T cells. This was probably due to the correlated decrease in MAdCAM-1 positive and increase in PNAd positive blood vessels in the tumour mucosa. There were also fewer CXCR3+ T lymphocytes in the tumour tissue. These findings provide evidence that endothelial cells within tumours arising at mucosal sites do not support extravasation of typical mucosa-infiltrating T cells. This may be of major relevance for future immunotherapeutic strategies for treatment of GC.
Keyword
- Adenocarcinoma/*immunology
- Aged
- Aged
- 80 and over
- Antigens
- Surface/metabolism
- CD4-Positive T-Lymphocytes/immunology
- CD8-Positive T-Lymphocytes/immunology
- Cell Movement/*immunology
- Female
- Gastric Mucosa/*immunology
- Humans
- Immunoglobulins/metabolism
- Male
- Membrane Proteins/metabolism
- Middle Aged
- Mucoproteins/metabolism
- Receptors
- Cell Surface/metabolism
- Receptors
- Chemokine/metabolism
- Receptors
- Lymphocyte Homing/*immunology
- Stomach Neoplasms/*immunology
- T-Lymphocyte Subsets/immunology
- T-Lymphocytes/*immunology
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- By the author/editor
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Enarsson, Karin, ...
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Johnsson, Erik, ...
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Lindholm, Cathar ...
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Lundgren, Anna, ...
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Pan-Hammarström, ...
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Strömberg, Erika ...
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show more...
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Bergin, Philip, ...
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Baunge, E. L.
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Svennerholm, Ann ...
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Quiding-Järbrink ...
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- Articles in the publication
- Clin Immunol
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Clinical Immunol ...
- By the university
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University of Gothenburg
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Karolinska Institutet