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Association analysi...
Association analysis of MYO9B gene polymorphisms with celiac disease in a Swedish/Norwegian cohort
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Amundsen, S. S. (author)
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Monsuur, A. J. (author)
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Wapenaar, M. C. (author)
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Lie, B. A. (author)
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Ek, J. (author)
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- Gudjonsdottir, Audur, 1959 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences
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- Ascher, Henry, 1953 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences
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Wijmenga, C. (author)
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Sollid, L. M. (author)
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(creator_code:org_t)
- Elsevier BV, 2006
- 2006
- English.
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In: Hum Immunol. - : Elsevier BV. - 0198-8859. ; 67:4-5, s. 341-5
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Association between myosin IXB (MYO9B) gene variants and celiac disease (CD) has been reported in a study of a Dutch cohort. Six single nucleotide polymorphisms (SNPs) within the 3' part of the MYO9B gene showed significant genetic association and formed an associated haplotype. The current study aimed to replicate these findings in a Swedish/Norwegian cohort. Genotyping of the three SNPs which tagged the associated haplotype was performed in a CD family dataset (n = 326) and in an additional set of healthy controls (n = 562). Although our material provided reasonable power to detect the previously observed association, we were unable to replicate association with these SNPs. Lack of reproducibility could be explained by no or negligible contribution of MYO9B to the genetic predisposition to CD in the Swedish/Norwegian population. Alternatively, it might be due to variable linkage disequilibria in distinct populations in the tested SNPs and a causative mutation yet to be identified or to false positive findings (type I error) in the Dutch study.
Keyword
- Celiac Disease/*epidemiology/*genetics
- Cohort Studies
- Epidemiology
- Molecular
- European Continental Ancestry Group/*genetics
- Female
- Genetic Predisposition to Disease
- Humans
- Linkage Disequilibrium
- Male
- Myosins/*genetics
- Norway/epidemiology
- *Polymorphism
- Single Nucleotide
- Sweden/epidemiology
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Amundsen, S. S.
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Monsuur, A. J.
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Wapenaar, M. C.
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Lie, B. A.
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Ek, J.
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Gudjonsdottir, A ...
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show more...
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Ascher, Henry, 1 ...
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Wijmenga, C.
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Sollid, L. M.
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show less...
- Articles in the publication
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Hum Immunol
- By the university
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University of Gothenburg