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Association analysi...
Association analysis of MYO9B gene polymorphisms with celiac disease in a Swedish/Norwegian cohort
- Article/chapterEnglish2006
Publisher, publication year, extent ...
Numbers
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LIBRIS-ID:oai:gup.ub.gu.se/53487
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https://gup.ub.gu.se/publication/53487URI
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https://doi.org/10.1016/j.humimm.2006.03.020DOI
Supplementary language notes
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Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Association between myosin IXB (MYO9B) gene variants and celiac disease (CD) has been reported in a study of a Dutch cohort. Six single nucleotide polymorphisms (SNPs) within the 3' part of the MYO9B gene showed significant genetic association and formed an associated haplotype. The current study aimed to replicate these findings in a Swedish/Norwegian cohort. Genotyping of the three SNPs which tagged the associated haplotype was performed in a CD family dataset (n = 326) and in an additional set of healthy controls (n = 562). Although our material provided reasonable power to detect the previously observed association, we were unable to replicate association with these SNPs. Lack of reproducibility could be explained by no or negligible contribution of MYO9B to the genetic predisposition to CD in the Swedish/Norwegian population. Alternatively, it might be due to variable linkage disequilibria in distinct populations in the tested SNPs and a causative mutation yet to be identified or to false positive findings (type I error) in the Dutch study.
Subject headings and genre
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Celiac Disease/*epidemiology/*genetics
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Cohort Studies
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Epidemiology
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Molecular
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European Continental Ancestry Group/*genetics
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Female
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Genetic Predisposition to Disease
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Humans
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Linkage Disequilibrium
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Male
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Myosins/*genetics
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Norway/epidemiology
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*Polymorphism
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Single Nucleotide
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Sweden/epidemiology
Added entries (persons, corporate bodies, meetings, titles ...)
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Monsuur, A. J.
(author)
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Wapenaar, M. C.
(author)
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Lie, B. A.
(author)
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Ek, J.
(author)
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Gudjonsdottir, Audur,1959Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences(Swepub:gu)xgudau
(author)
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Ascher, Henry,1953Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences(Swepub:gu)xasche
(author)
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Wijmenga, C.
(author)
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Sollid, L. M.
(author)
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Göteborgs universitetInstitutionen för kliniska vetenskaper
(creator_code:org_t)
Related titles
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In:Hum Immunol: Elsevier BV67:4-5, s. 341-50198-8859
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Amundsen, S. S.
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Monsuur, A. J.
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Wapenaar, M. C.
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Lie, B. A.
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Ek, J.
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Gudjonsdottir, A ...
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Ascher, Henry, 1 ...
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Wijmenga, C.
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Sollid, L. M.
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- Articles in the publication
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Hum Immunol
- By the university
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University of Gothenburg