onr:"swepub:oai:gup.ub.gu.se/53658"
Search: onr:"swepub:oai:gup.ub.gu.se/53658" > Pronounced inductio...
- 1 of 1
- Previous record
- Next record
- To hitlist
Pronounced induction of testicular PGF(2 alpha) and suppression of testosterone by cadmium-prevention by zinc.
-
- Gunnarsson, David (author)
- Umeå universitet,Institutionen för molekylärbiologi (Teknisk-naturvetenskaplig fakultet)
-
- Svensson, Mona (author)
- Umeå universitet,Yrkes- och miljömedicin
-
- Selstam, Gunnar (author)
- Umeå universitet,Institutionen för molekylärbiologi (Medicinska fakulteten)
- show more...
- show less...
- (creator_code:org_t)
- Elsevier BV, 2004
- 2004
- English.
- In: Toxicology. - : Elsevier BV. - 0300-483X .- 1879-3185. ; 200:1, s. 49-58
- Journal article (peer-reviewed)
Abstract
Subject headings
Close
- In order to investigate the effects of cadmium (Cd) on testicular prostaglandin F(2 alpha) (PGF(2 alpha)) production, adult male Sprague-Dawley rats were exposed to CdCl(2) by subcutaneous injections. Dose-response as well as temporal-response experiments were performed, and PGF(2 alpha) levels were determined by radioimmunoassay (RIA). The highest cadmium dose (10 micromol/kg) caused a dramatic elevation of testicular PGF(2 alpha), which was established to occur 48 h after exposure. At this point of time, cadmium-treated animals displayed PGF(2 alpha) levels 16.7 times higher than saline-injected controls. No significant differences were found with the lower doses used (1 and 5 micromol/kg). In addition, the influence of pre-treatment with zinc (Zn) was assessed. The very strong stimulatory effect on PGF(2 alpha) synthesis (22.3-fold) detected after exposure to 20 micromol/kg cadmium, was completely absent in the group given zinc (1 mmol/kg) prior to cadmium exposure. Plasma testosterone concentrations were determined in the three experiments, and all groups with strongly elevated PGF(2 alpha) levels showed drastically lowered concentrations of testosterone. Zinc pre-treatment abolished not only the cadmium-induced rise in PGF(2 alpha) but also the testosterone reduction. Additionally, cadmium was found to inhibit the expression of steroidogenic acute regulatory protein (StAR), which is responsible for the rate-limiting step in steroidogenesis. The present findings establish that cadmium can cause a strong induction of testicular PGF(2 alpha) production, which might help to explain the well-known antisteroidogenic effect of this heavy metal. Such an inhibitory effect could be due to reduced levels of StAR.
Keyword
- Analysis of Variance
- Animals
- Cadmium Chloride
- antagonists & inhibitors
- toxicity
- Dinoprost
- biosynthesis
- Leydig Cells
- drug effects
- metabolism
- Male
- Phosphoproteins
- drug effects
- metabolism
- Radioimmunoassay
- Rats
- Rats
- Sprague-Dawley
- Testis
- drug effects
- metabolism
- Testosterone
- biosynthesis
- blood
- Zinc
- pharmacology
- Cadmium; Rat; Prostaglandin F2α (PGF2α); Steroidogenic acute regulatory protein (StAR); Testis; Testosterone
Publication and Content Type
- ref (subject category)
- art (subject category)
- 1 of 1
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Gunnarsson, Davi ...
- Svensson, Mona
- Selstam, Gunnar
- Nordberg, Gunnar ...
- Articles in the publication
- Toxicology
- By the university
- University of Gothenburg
- Umeå University
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
