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A prospective study...
A prospective study of adiposity and postmenopausal breast cancer risk: the Malmö Diet and Cancer Study
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Lahmann, Petra H (author)
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- Lissner, Lauren, 1956 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för samhällsmedicin, Avdelningen för allmänmedicin,Institute of Community Medicine, Dept of Primary Health Care
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Gullberg, Bo (author)
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Olsson, Håkan (author)
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Berglund, Göran (author)
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(creator_code:org_t)
- 2003
- 2003
- English.
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In: International Journal of Cancer. ; 103, s. 246-252
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Abstract
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- Department of Medicine, Lund University, Malmö University Hospital, Malmö, Sweden. lahmann@mail.dife.de High BMI is a well-known risk factor for postmenopausal breast cancer. There have been some reports of excess risk in association with weight gain and WHR, but little is known about the influence of body fatness per se. Using data from the Malmö Diet and Cancer Study, a prospective cohort study, 12,159 postmenopausal women (59.9 +/- 7.7 years) were categorized by quintiles of baseline anthropometric and impedance measures and reported weight change since age 20. RRs from multivariate Cox regression models were calculated. All analyses were adjusted for age, height, smoking, alcohol consumption, occupation, marital status, parity, age at first pregnancy, age at menarche and current hormone use. During the 5.7 years of follow-up, there were 246 incident breast cancer cases. Weight, height, BMI and %BF were positively associated with risk of breast cancer (p(trend) 21 kg (top quintile) had an RR of 1.75 (95% CI 1.11-2.77) compared to women with low weight gain. Breast cancer risk in postmenopausal women is predicted by increased body fat and weight gain. %BF is a more discriminating risk factor for breast cancer incidence than the commonly used BMI. Copyright 2002 Wiley-Liss, Inc. PMID: 12455040 [PubMed - indexed for MEDLINE]
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Keyword
- obesity • breast cancer • body fat • weight gain • central adiposity • hormone use • European Prospective Investigation into Cancer and Nutrition
Publication and Content Type
- ref (subject category)
- art (subject category)
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