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Mature-onset obesit...
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García, Maria CGothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory
(author)
Mature-onset obesity in interleukin-1 receptor I knockout mice.
- Article/chapterEnglish2006
Publisher, publication year, extent ...
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American Diabetes Association,2006
Numbers
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LIBRIS-ID:oai:gup.ub.gu.se/53867
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https://gup.ub.gu.se/publication/53867URI
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https://doi.org/10.2337/db05-1304DOI
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https://lup.lub.lu.se/record/410493URI
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Interleukin-1 (IL-1) is a major mediator of inflammation that exerts its biological activities through the IL-1 type I receptor (IL-1RI). The body weights of IL-1RI(-/-) mice of both sexes started to deviate from those of wild-type mice at 5-6 months of age and were 20% higher at 9 months of age. Visceral and subcutaneous fat mass, measured by dual-energy X-ray absorptiometry and magnetic resonance imaging, was markedly (1.5- to 2.5-fold) increased. Lean body mass and crown-rump length were also slightly (11 and 5%, respectively) increased, as was serum IGF-I. Obese IL-1RI(-/-) mice were insulin resistant, as evidenced by hyperinsulinemia, decreased glucose tolerance, and insulin sensitivity. To elucidate the mechanisms for the development of obesity, young pre-obese IL-1RI(-/-) mice were investigated. They showed decreased suppression of body weight and food intake in response to systemic leptin treatment. The decreased leptin responsiveness was even more pronounced in older obese animals. Moreover, spontaneous locomotor activity and fat utilization, as measured by respiratory quotient, were decreased in pre-obese IL-1RI(-/-) mice. In conclusion, lack of IL-1RI-mediated biological activity causes mature-onset obesity. This obese phenotype is preceded by decreased leptin sensitivity, fat utilization, and locomotor activity.
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Wernstedt, Ingrid,1978Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory(Swepub:gu)xwerni
(author)
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Berndtsson, Anna,1979Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory(Swepub:gu)xbannl
(author)
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Enge, Maria,1970Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory(Swepub:gu)xenmar
(author)
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Bell, Michal,1974Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk genetik och klinisk genetik,Institute of Biomedicine, Department of Medical and Clinical Genetics
(author)
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Hultgren, Olof H.,1970Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi,Institute of Biomedicine, Department of Microbiology and Immunology(Swepub:gu)xhulol
(author)
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Horn, MichaelGothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences(Swepub:gu)xhormi
(author)
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Ahrén, BoLund University,Lunds universitet,Medicin, Lund,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Medicine, Lund,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)med-bah
(author)
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Enerbäck, Sven,1958Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk genetik och klinisk genetik,Institute of Biomedicine, Department of Medical and Clinical Genetics(Swepub:gu)xenesv
(author)
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Ohlsson, Claes,1965Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin,Institute of Medicine, Department of Internal Medicine(Swepub:gu)xohlcl
(author)
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Wallenius, Ville,1970Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory(Swepub:gu)xwalvi
(author)
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Jansson, John-Olov,1954Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory(Swepub:gu)xjanjo
(author)
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Göteborgs universitetWallenberglaboratoriet
(creator_code:org_t)
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In:Diabetes: American Diabetes Association55:5, s. 1205-130012-17971939-327X
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Diabetes
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University of Gothenburg
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Lund University